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Disease on EC 2.7.11.10 - IkappaB kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
Acute Kidney Injury
Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response.
Acute Lung Injury
[Potential molecular mechanism of multiple organ dysfunction syndrome induced by hemorrhage and endotoxin]
Adenocarcinoma
Cytokine-activated degradation of inhibitory kappaB protein alpha is inhibited by the short-chain fatty acid butyrate.
GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability.
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers.
Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.
Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell.
Adenocarcinoma of Lung
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis.
Adenoma
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Adenomyosis
Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis.
Adenoviridae Infections
Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.
Agammaglobulinemia
Autosomal-dominant primary immunodeficiencies.
Alzheimer Disease
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Amyotrophic Lateral Sclerosis
A novel TBK1 mutation in a family with diverse frontotemporal dementia spectrum disorders.
ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation.
Association of the New Variant Tyr424Asp at TBK1 Gene with Amyotrophic Lateral Sclerosis and Cognitive Decline.
Autophagy and ALS: mechanistic insights and therapeutic implications.
Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes.
Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS.
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.
Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis.
Genetic and functional analysis of TBK1 variants in Korean patients with sporadic amyotrophic lateral sclerosis.
Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.
Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort.
Screening of the TBK1 gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin.
TBK1 is associated with ALS and ALS-FTD in Sardinian patients.
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
TBK1 mutations in Italian patients with amyotrophic lateral sclerosis: genetic and functional characterisation.
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.
UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway.
[A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene].
Anaphylaxis
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.
Anthrax
Anthrax lethal toxin enhances IkappaB kinase activation and differentially regulates pro-inflammatory genes in human endothelium.
Arthritis
Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.
Amelioration of Arthritis by Intraarticular Dominant Negative IKKbeta Gene Therapy Using Adeno-Associated Virus Type 5.
IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint.
Periodic, Partial Inhibition of IKK{beta}-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis.
Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta.
The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.
Therapeutic effects of a TBK1 kinase inhibitor in germinal center-driven, autoantibody-mediated inflammatory arthritis.
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arthritis, Experimental
Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.
Amelioration of Arthritis by Intraarticular Dominant Negative IKKbeta Gene Therapy Using Adeno-Associated Virus Type 5.
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.
Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation.
Periodic, Partial Inhibition of IKK{beta}-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis.
Arthritis, Rheumatoid
Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.
Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
IkappaBalpha promoter polymorphisms in patients with rheumatoid arthritis.
IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
Inhibitor IkappaBalpha promoter functional polymorphisms in patients with rheumatoid arthritis.
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase.
Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome.
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Asthma
Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells.
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice.
Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.
Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation.
IkappaB kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma.
Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.
Selective blockade of NF-kappaB by novel mutated IkappaBalpha suppresses CD3/CD28-induced activation of memory CD4+ T cells in asthma.
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.
[Studies on the effect of Ginkgo biloba extracts on NF-kappaB pathway]
Astrocytoma
Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma.
Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol.
Ataxia
Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.
Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Ataxia Telangiectasia
ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin.
Molecular Linkage Between the Kinase ATM and NF-{kappa}B Signaling in Response to Genotoxic Stimuli.
Nickel carcinogenesis mechanism: cell cycle dysregulation.
Atherosclerosis
Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Inhibition of cytokine-induced IkappaB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice.
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions.
Autoimmune Diseases
A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development.
IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
Recent progress in small molecule TBK1 inhibitors: a patent review (2015- 2020).
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.
Bacterial Infections
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor.
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
TBK1 protects vacuolar integrity during intracellular bacterial infection.
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.
Barrett Esophagus
Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma.
Bone Resorption
Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy.
IKK{beta} as a target for treatment of inflammation induced bone loss.
Brain Injuries
alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation.
Brain Injuries, Traumatic
NF-kappaB and IkappaBalpha expression following traumatic brain injury to the immature rat brain.
Brain Ischemia
Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats.
Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia.
Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia.
Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice.
Brain Neoplasms
IkappaBalpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappaB in normal rat astrocytes and human brain tumour cells.
Breast Neoplasms
A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.
All roads lead to IKKepsilon.
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis.
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.
Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha.
IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines.
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.
Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.
Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.
Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids.
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance.
Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway.
Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-kappaB noncanonical and canonical pathway activation.
Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells.
Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis.
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.
Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms.
Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.
shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer.
Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta.
SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death.
Targeting the NF-kappaB pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs.
The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells.
The IKK/NF-?B signaling pathway requires Morgana to drive breast cancer metastasis.
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
[The nuclear factor kappa B activation: the key step of cell proliferation in estrogen receptor-negative breast cancer cells]
Bronchitis, Chronic
[Mangiferin protects rats against chronic bronchitis via regulating NF-kappaB (P65) and IkappaBalpha expression in mononuclear cells].
Burkitt Lymphoma
Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappaB inhibitory proteins IkappaBalpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells.
calpain-3 deficiency
Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the IkappaBalpha/NF-kappaB survival pathway in skeletal muscle.
Carcinogenesis
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines.
A review on the role of TANK-binding kinase 1 signaling in cancer.
Assessment of TANK-binding kinase 1 as a therapeutic target in cancer.
Attribution of NF-?B Activity to CHUK/IKK?-Involved Carcinogenesis.
Binding of manumycin A inhibits IkappaB kinase beta activity.
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG.
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers.
Inhibitor of kappaB Kinase Beta Regulates Gastric Carcinogenesis via Interleukin-1alpha Expression.
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.
Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells.
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
Role of IkappaB kinase in tumorigenesis.
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.
[Expression of nuclear transcription factor kappaB in hamster buccal pouch carcinogenesis]
Carcinoma
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
Aberrant expression of interferon regulatory factor 3 in human lung cancer.
Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells.
Adriamycin activates NF-kappaB in human lung carcinoma cells by IkappaBalpha degradation.
Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells.
Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor.
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.
Effects of IkappaB kinase alpha on the differentiation of squamous carcinoma cells.
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells.
Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression.
Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.
Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma.
High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity.
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.
IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.
Impaired activation of NFkappaB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IkappaBalpha.
Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma.
Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids.
Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter.
NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53.
Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells.
The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression.
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
The ubiquitin-proteasome pathway and enhanced activity of NF-kappaB in gastric carcinoma.
Carcinoma in Situ
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Hepatocellular
Binding of manumycin A inhibits IkappaB kinase beta activity.
Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8.
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Freeze-dried grape powder attenuates mitochondria- and oxidative stress-mediated apoptosis in liver cells.
Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas.
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes.
Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells.
Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB.
NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.
TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells.
TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes.
[Enhancement of HepG2 cell radiosensitivity by mutant IkappaBalpha gene transfection.]
Carcinoma, Non-Small-Cell Lung
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.
Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.
Carcinoma, Ovarian Epithelial
Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.
Carcinoma, Renal Cell
Impaired activation of NFkappaB in T cells from a subset of renal cell carcinoma patients is mediated by inhibition of phosphorylation and degradation of the inhibitor, IkappaBalpha.
Carcinoma, Squamous Cell
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
Aberrant expression of interferon regulatory factor 3 in human lung cancer.
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Effects of IkappaB kinase alpha on the differentiation of squamous carcinoma cells.
Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.
High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity.
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.
IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.
NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.
Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Carcinosarcoma
Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.
Cardiomegaly
Astragaloside IV protects against the pathological cardiac hypertrophy in mice.
Suppressor of IKK? is an essential negative regulator of pathological cardiac hypertrophy.
Chlamydia Infections
Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia.
Chondrosarcoma
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
Classical Swine Fever
Classical swine fever virus non-structural protein 4B binds tank-binding kinase 1.
The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.
Coinfection
Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.
Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways.
Functional characterization of a purified, recombinant NF-kappaB/IkappaB complex.
Colitis
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide.
An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.
Attenuation of NF-?B in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis.
Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis.
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Nuclear factor-kappa B in intestinal protection and destruction.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis.
Colitis, Ulcerative
Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis.
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
[Effect of Kuijieling decoction on proteins expression of IKK-alpha in colonic mucosa of ulcerative colitis model rats]
Colitis-Associated Neoplasms
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Colonic Neoplasms
A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.
Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis.
Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells.
Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells.
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Mapping of the critical region of mitogene-inducible gene-6 for NF-kappaB activation.
Sulindac inhibits activation of the NF-kappaB pathway.
Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells.
The tumor-suppressive reagent taurolidine is an inhibitor of protein biosynthesis.
[The role of NF-kappaB in colon cancer].
Colorectal Neoplasms
A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase ? in colorectal cancer
Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma.
Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells.
Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.
Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation.
Prolyl Hydroxylase-3 Is Downregulated in Colorectal Cancer Cells and Inhibits IKKbeta, Independent of Hydroxylase Activity.
Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).
The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB.
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.
Communicable Diseases
Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells.
Corneal Ulcer
Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture.
Coronary Occlusion
Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha.
Cowpox
Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.
Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.
Crohn Disease
Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease.
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Cystic Fibrosis
Anti-inflammatory gene therapy directed at the airway epithelium.
Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway.
High susceptibility for cystic fibrosis human airway gland cells to produce IL-8 through the I kappa B kinase alpha pathway in response to extracellular NaCl content.
Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.
Dementia
Gene mutations in a Han Chinese Alzheimer's disease cohort.
Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila.
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
[A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene].
Dermatitis
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
IKKbeta Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis.
Diabetes Mellitus
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Diabetes Mellitus, Type 1
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Inhibition of TBK1/IKK? Promotes Regeneration of Pancreatic ?-cells.
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.
Diabetes Mellitus, Type 2
Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling.
Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice.
Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes.
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Prevention of fat-induced insulin resistance by salicylate.
Reduced Skeletal Muscle Inhibitor of {kappa}B{beta} Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training.
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Down Syndrome
Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effects.
Dysautonomia, Familial
ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.
Episodic somnolence in an infant with Riley-Day syndrome.
Genomic organization and chromosomal localization of the mouse IKBKAP gene.
IKBKAP mRNA in peripheral blood leukocytes: a molecular marker of gene expression and splicing in familial dysautonomia.
Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.
Specific correction of a splice defect in brain by nutritional supplementation.
Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia.
Ectodermal Dysplasia
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.
Anhidrotic ectodermal dysplasia and immunodeficiency: the role of NEMO.
Autosomal-dominant primary immunodeficiencies.
Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation.
Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency.
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.
Inherited disorders of NF-kappaB-mediated immunity in man.
Encephalitis
alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation.
Encephalomyelitis
Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.
Encephalomyelitis, Autoimmune, Experimental
Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.
Endometrial Neoplasms
Expression of inflammatory cytokines by adipose tissue from patients with endometrial cancer.
Endometriosis
Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis.
Nuclear factor kappaB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis.
Endotoxemia
4-O-Methylgallic acid suppresses inflammation-associated gene expression by inhibition of redox-based NF-kappaB activation.
Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei.
Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.
Role of NFkappaB in the mortality of sepsis.
[Sophoridine inhibits NF-kappaB signaling pathway activation in kidney tissue of endotoxemia mice].
Eosinophilia
Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation.
Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
Epilepsy
NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks.
Erectile Dysfunction
IkappaB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum.
Escherichia coli Infections
Escherichia coli up-regulates proinflammatory cytokine expression in granulocyte/macrophage lineages of CD34 stem cells via p50 homodimeric NF-kappaB.
Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli.
Esophageal Neoplasms
Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB.
Exanthema
I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.
Eye Infections
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Fatty Liver
Animal models of steatohepatitis.
Fibrosarcoma
Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin.
Lymphotoxin-beta receptor activation by lymphotoxin-alpha(1)beta(2) and LIGHT promotes tumor growth in an NFkappaB-dependent manner.
Frontotemporal Dementia
A novel TBK1 mutation in a family with diverse frontotemporal dementia spectrum disorders.
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Autophagy and ALS: mechanistic insights and therapeutic implications.
Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes.
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.
Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.
Rare TBK1 variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort.
TBK1 is associated with ALS and ALS-FTD in Sardinian patients.
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated frontotemporal dementia: A longitudinal case report.
Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.
Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature.
[A Pair of Siblings with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and a Novel Thr462Lysfs Mutation in the TBK1 Gene].
Frontotemporal Lobar Degeneration
ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation.
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Gastritis
Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.
Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells.
Genetic Diseases, Inborn
ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.
Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia.
Glaucoma
Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients.
Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells.
Transgenic TBK1 mice have features of normal tension glaucoma.
Glioblastoma
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.
Multiple forms of protein kinase from normal human brain and glioblastoma.
The regulating role of mutant IkappaBalpha in expression of TIMP-2 and MMP-9 in human glioblastoma multiform.
Glioma
Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas.
alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation.
Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.
Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells.
Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas.
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production.
Glomerulosclerosis, Focal Segmental
Increased nuclear factor-kappaB and angiotensinogen gene expression in posttransplant recurrent focal segmental glomerulosclerosis.
Glucose Intolerance
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
Granulosa Cell Tumor
Characterization of the Inhibitor of KappaB Kinase (IKK) Complex in Granulosa Cell Tumors of the Ovary and Granulosa Cell Tumor-Derived Cell Lines.
Head and Neck Neoplasms
Curcumin Treatment Suppresses IKK{beta} Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study.
Hematologic Neoplasms
Mutational analysis of IkappaBalpha in hematologic malignancies.
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.
Hemorrhagic Fevers, Viral
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Hepatitis
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.
Hepatitis B
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.
IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C.
Stimulation of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKK?/IRF3 signalling.
Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB.
Hepatitis C
Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway.
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase.
Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease.
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
Hepatitis E
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells.
Herpes Simplex
Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.
Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes.
HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha.
HIV Infections
Disruption of MAP kinase activation and nuclear factor binding to the IL-12 p40 promoter in HIV-infected myeloid cells.
Ikappakappa mediates NF-kappaB activation in human immunodeficiency virus-infected cells.
Hodgkin Disease
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications.
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.
Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma.
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Mutations in the genes coding for the NF-{kappa}B regulating factors I{kappa}B{alpha} and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma.
Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.
Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.
[Preliminary analysis of mutations in exon 5 of IkappaBalpha gene in Hodgkin lymphoma]
Hyperalgesia
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-?B dependent genes.
Hyperlipidemias
Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner.
Hypersensitivity
Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells.
Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter.
Hypotension
Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock.
Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock.
Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.
ikappab kinase deficiency
Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells.
Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression.
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
Inhibition of NF-kappaB stabilizes gadd45alpha mRNA.
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Relationship between IkappaBalpha deficiency, NFkappaB activity and interleukin-8 production in CF human airway epithelial cells.
Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta.
Infections
A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-?B signaling.
A role for I{kappa}B kinase 2 in bipolar spindle assembly.
Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells.
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells.
Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells.
Activation of non-canonical NF-{kappa}B signaling by the oncoprotein TIO.
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
Activation of the virus-induced IKK/NF-kappaB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells.
An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
Apoptosis of dedifferentiated hepatoma cells is independent of NF-kappaB activation in response to LPS.
Autosomal-dominant primary immunodeficiencies.
Bacterial Muramyl Dipeptide (MDP) Restricts Human Cytomegalovirus Replication via an IFN-?-Dependent Pathway.
Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression.
Ca(2+) /calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection.
Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor.
Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013.
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.
Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma.
Control of the NF-kappaB inhibitor IkappaBalpha in pathogen infection.
Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.
CRISPR/Cas9-Mediated Chicken TBK1 Gene Knockout and Its Essential Role in STING-Mediated IFN-? Induction in Chicken Cells.
Ctenopharyngodon idella TBK1 activates innate immune response via IRF7.
Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells.
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway.
Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation.
Enhancement of lipopolysaccharide-stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirus-mediated inhibition of inhibitory kappa B kinase signalling.
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Escherichia coli up-regulates proinflammatory cytokine expression in granulocyte/macrophage lineages of CD34 stem cells via p50 homodimeric NF-kappaB.
H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells.
Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells.
Helicobacter pylori infection activates NF-kappaB signaling pathway to induce iNOS and protect human gastric epithelial cells from apoptosis.
Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation.
Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.
Host and parasite-derived IKK activities direct distinct temporal phases of NF-{kappa}B activation and target gene expression following Toxoplasma gondii infection.
Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication.
Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation.
I kappa B kinase alpha (IKK?) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells.
Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells.
IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.
Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway.
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells.
Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression.
Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli.
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.
Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo.
InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity.
Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.
Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.
MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection.
Molecular cloning of IKKbeta from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection.
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.
Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway.
NF-?B activation coordinated by IKK? and IKK? enables latent infection of Kaposi's sarcoma-associated herpesvirus.
NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.
NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.
NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha.
NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection.
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
NF-kappaB: linking inflammation and immunity to cancer development and progression.
NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.
Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors.
Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells.
Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells.
Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein.
Porcine arterivirus activates the NF-kappaB pathway through IkappaB degradation.
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-? production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway.
Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor.
Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.
Protein kinase of bacteriophage T7. 1. Purification.
Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells.
Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7.
Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes.
Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.
Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions.
Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism.
Selective inhibition of inhibitory kappa B kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells.
Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death.
Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-mediated apoptosis.
Specific deficiency in nuclear factor-kappaB activation in neurons of the central nervous system.
Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions.
TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion.
The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription.
The major component of IkappaBalpha proteolysis occurs independently of the proteasome pathway in respiratory syncytial virus-infected pulmonary epithelial cells.
The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.
The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers.
The role of IKK? in Venezuelan equine encephalitis virus infection.
The role of the IKK complex in viral infections.
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation.
Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKK? Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis.
Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro.
Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
Inflammatory Bowel Diseases
An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.
Inflammatory Breast Neoplasms
Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade.
Influenza, Human
HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase.
The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells.
Insulin Resistance
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.
An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice.
Animal models of steatohepatitis.
Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice.
Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta.
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation.
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance.
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B.
Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice.
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet.
High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity.
HSP72 protects against obesity-induced insulin resistance.
Hypertension and insulin resistance are not directly related in obese dogs.
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet.
IKK-beta links inflammation to obesity-induced insulin resistance.
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance.
IRS-1 regulation in health and disease.
Is NF-kappaB a culprit in type 2 diabetes?
JNK1 and IKK{beta}: molecular links between obesity and metabolic dysfunction.
L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
Mechanism for improved insulin sensitivity after gastric bypass surgery.
Molecular mechanism of interactions between Chrysin and I-kappa-B kinase epsilon (IKKe)/Tank Binding Kinase-1(TBK1): Cell based assay and insilico molecular docking studies.
Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases.
Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Prevention of fat-induced insulin resistance by salicylate.
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
Review article: diabetes and atherosclerosis--running on a common road.
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome.
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
The obese healthy paradox: is inflammation the answer?
The protein kinase IKKepsilon regulates energy balance in obese mice.
Variant in the 3' Region of the IkappaBalpha Gene Associated With Insulin Resistance in Hispanic Americans: The IRAS Family Study.
[Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet]
Klatskin Tumor
Effect of mutated IkappaBalpha transfection on multidrug resistance in hilar cholangiocarcinoma cell lines.
Latent Infection
Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway.
Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.
New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection.
NF-?B activation coordinated by IKK? and IKK? enables latent infection of Kaposi's sarcoma-associated herpesvirus.
Leukemia
1alpha,25-dihydroxyvitamin D3 stimulates phosphorylation of IkappaBalpha and synergizes with TPA to induce nuclear translocation of NFkappaB during monocytic differentiation of NB4 leukemia cells.
An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism.
Critical roles of I?B kinase subunits in mast cell degranulation.
Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells.
Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation.
IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Inhibition of NF-kappaB by mutant IkappaBalpha enhances TNF-alpha-induced apoptosis in HL-60 cells by controlling bcl-xL expression.
Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-kappaB noncanonical and canonical pathway activation.
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma.
Siva-1 Promotes K-48 Polyubiquitination of TRAF2 and Inhibits TCR-Mediated Activation of NF-kappaB.
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.
Leukemia, Erythroblastic, Acute
NF-kappaB transcription factors are involved in normal erythropoiesis.
Leukemia, Hairy Cell
Mutational analysis of IkappaBalpha in hematologic malignancies.
Leukemia, Lymphocytic, Chronic, B-Cell
p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541.
Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvement.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Leukemia, Myeloid
Mutational analysis of IkappaBalpha in hematologic malignancies.
Leukemia, Myeloid, Acute
Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts.
Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Leukemia, T-Cell
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein.
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.
Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells.
Downregulation of active IKK beta by Ro52-mediated autophagy.
Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins.
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.
IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.
In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax.
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.
Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.
Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma.
Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.
Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions.
The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta.
Leukemia-Lymphoma, Adult T-Cell
Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions.
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells.
Leukopenia
Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock.
Liver Cirrhosis
Angiotensin II Activates IkappaB Kinase Phosphorylation of RelA at Ser(536) to Promote Myofibroblast Survival and Liver Fibrosis.
Dual TBK1/IKK? inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice.
Liver Diseases
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Liver Failure
Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality.
p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.
Liver Neoplasms
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo.
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Low Tension Glaucoma
Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients.
Lung Diseases
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.
Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.
Lung Injury
Duration and Intensity of NF-{kappa}B Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury.
Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome.
[Effects of nuclear factor-kappaB on ventilator induced lung biotrauma by higher tidal volume and its interaction with pro-inflammatory cytokines]
Lung Neoplasms
Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells.
Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation.
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells.
Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing RelA acetylation in A549 lung cancer cells.
Gene transfer of inhibitor kappaB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo.
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling.
Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell.
Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.
Using RNA Interference in Lung Cancer Cells to Target the IKK-NF-?B Pathway.
[Inhibition of NF-kappaB through IkappaBalpha transfection affects invasion of human lung cancer cell line A549]
Lupus Erythematosus, Systemic
I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.
Lyme Disease
Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.
Lymphadenopathy
Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice.
Lymphoma
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications.
Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism.
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.
I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma.
Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma.
IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.
Interleukin-13-induced type II polarization of inflammatory macrophages is mediated through suppression of nuclear factor-kappaB and preservation of IkappaBalpha in a T cell lymphoma.
KSHV vFLIP binds to IKK-gamma to activate IKK.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Oncogenic activation of NF-kappaB.
Protein phosphorylation as a key mechanism for the regulation of BCL-3 activity.
Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level.
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line.
TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.
Lymphoma, B-Cell
A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma.
Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.
Lymphoma, Large B-Cell, Diffuse
A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma.
Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.
Lymphoma, Mantle-Cell
Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level.
Lymphoma, Primary Effusion
KSHV vFLIP binds to IKK-gamma to activate IKK.
Lymphoma, T-Cell
Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism.
Interleukin-13-induced type II polarization of inflammatory macrophages is mediated through suppression of nuclear factor-kappaB and preservation of IkappaBalpha in a T cell lymphoma.
Lymphoma, T-Cell, Cutaneous
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents.
Malaria
FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.
Measles
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Melanoma
BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.
Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells.
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA.
Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription.
Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7.
Influenza A Virus PA Antagonizes Interferon-? by Interacting with Interferon Regulatory Factor 3.
KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment.
Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.
mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB.
Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy.
N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.
NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways.
Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks.
Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth.
The IKK?-dependent non-canonical pathway of NF-?B activation is constitutively active and modulates progression-related functions in a subset of human melanomas.
The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells.
The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model.
The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells.
Memory Disorders
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.
The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories.
Metabolic Diseases
IKKepsilon: a bridge between obesity and inflammation.
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.
Metabolic Syndrome
Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome.
Microcephaly
Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation.
Migraine Disorders
NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks.
Nuclear factor-kappaB as a molecular target for migraine therapy.
Motor Neuron Disease
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature.
Mouth Neoplasms
Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor.
Multiple Myeloma
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, induces apoptosis in multiple myeloma cells in an IkappaBalpha-independent manner.
Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells.
Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor.
Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma.
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma.
Multiple Sclerosis
Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.
Murine Acquired Immunodeficiency Syndrome
Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover.
Muscle Cramp
NF-kappaB-Dependent Induction of Cathelicidin-Related Antimicrobial Peptide in Murine Mast Cells by Lipopolysaccharide.
Muscular Atrophy
Inhibition of IkappaB kinase alpha (IKK?) or IKKbeta (IKK?) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.
Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy.
The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy.
The Proteasome Inhibitor MG132 Reduces Immobilization-Induced Skeletal Muscle Atrophy in Mice.
Muscular Disorders, Atrophic
The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy.
Muscular Dystrophies, Limb-Girdle
Beta-defensin overexpression induces progressive muscle degeneration in mice.
Myelodysplastic Syndromes
Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Myocardial Ischemia
Early activation of IKKbeta during in vivo myocardial ischemia.
Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart.
Myocardial Reperfusion Injury
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock 17(2):127-134, 2002.
Myocarditis
Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes.
Nasopharyngeal Carcinoma
Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-?B-independent and ERK-dependent pathway.
Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma.
[IkappaB alpha mRNA expression and its DNA sequence in nasopharyngeal carcinoma cell lines]
Neoplasm Metastasis
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.
Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-?B: implication in breast cancer metastasis.
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression.
IKK? inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line.
IKKalpha at the crossroads of inflammation and metastasis.
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis.
miR-146a suppresses invasion of pancreatic cancer cells.
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells.
Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
The Specific IKK?/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-?B and MAP Kinase Pathways.
Neoplasms
17-Acetoxyjolkinolide B irreversibly inhibits IkappaB kinase and induces apoptosis of tumor cells.
25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.
5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells.
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages.
A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase.
A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
A review on the role of TANK-binding kinase 1 signaling in cancer.
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha.
A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.
A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase ? in colorectal cancer
A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis.
Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes.
Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism.
Activation of NF-{kappa}B Signaling by Inhibitor of NF-{kappa}B Kinase {beta} Increases Aggressiveness of Ovarian Cancer.
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.
Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.
Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding.
Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.
Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock.
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
Adenovirus-mediated inhibitor kappaB gene transfer improves the chemosensitivity to anticancer drugs in human lung cancer in vitro and in vivo.
Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling.
African swine fever virus IAP-like protein induces the activation of nuclear factor kappa B.
AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.
All roads lead to mTOR: integrating inflammation and tumor angiogenesis.
An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.
An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4.
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.
Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells.
Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice.
Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species.
Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog.
Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
Arachidonic acid influences proinflammatory gene induction by stabilizing the inhibitor-kappaBalpha/nuclear factor-kappaB (NF-kappaB) complex, thus suppressing the nuclear translocation of NF-kappaB.
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.
Assessment of TANK-binding kinase 1 as a therapeutic target in cancer.
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.
Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha.
B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFkappaB pathways which enhances transcription of MnSOD by accelerating IkappaBalpha degradation in normal and cancer cells.
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.
Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha.
Bcl-2 intersects the NFkappaB signalling pathway and suppresses apoptosis in ventricular myocytes.
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis.
Bortezomib induces canonical NF-{kappa}B activation in multiple myeloma cells.
Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity.
Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression.
Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents.
Cantharidin-induced acute hepatotoxicity: the role of TNF-?, IKK-?, Bcl-2, Bax and caspase3.
Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells.
CARMA3 is Crucial for EGFR-Induced Activation of NF-{kappa}B and Tumor Progression.
Caspase cleavage product lacking amino-terminus of IkappaBalpha sensitizes resistant cells to TNF-alpha and TRAIL-induced apoptosis.
Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB.
Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells.
Characterization of NFkappaB activation by detection of green fluorescent protein-tagged IkappaB degradation in living cells.
Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
Characterization of the Inhibitor of KappaB Kinase (IKK) Complex in Granulosa Cell Tumors of the Ovary and Granulosa Cell Tumor-Derived Cell Lines.
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
Clinical implications of inflammatory cytokines in the cochlea: a technical note.
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.
Cloning and characterization of a homologue of the alpha inhibitor of NF-kappaB in Rainbow trout (Oncorhynchus mykiss).
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.
Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production.
Conjugated polyhydroxybenzene derivatives block tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation and cyclooxygenase-2 gene transcription by targeting IkappaB kinase activity.
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.
Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth.
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB.
Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/I?B Kinase ? (IKK?)/Nuclear Factor Kappa B (NF-?B) Pathway in Microglia.
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.
Current topics in pharmacological research on bone metabolism: osteoclast differentiation regulated by glycosphingolipids.
Cystatin cures visceral leishmaniasis by NF-?B-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway.
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.
Defective NF-kappaB activation in virus-infected neuronal cells is restored by genetic complementation.
Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.
Deguelin inhibits expression of IkappaBalpha protein in Raji and U937 cells.
Depletion of histone deacetylase protein: a common consequence of inflammatory cytokine signaling?
Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer.
Different modes of NF-kappaB/Rel activation in pancreatic lobules.
Differential activation of the IkappaBalpha and mouse mammary tumor virus promoters by progesterone and glucocorticoid receptors.
Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
Differential effects of Ras signaling through NFkappaB on skeletal myogenesis.
Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappaB inhibitory proteins IkappaBalpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells.
Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription.
Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells.
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.
Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-?) via extensive ligand-based modeling and virtual screening.
Divergent effect of proteasome inhibition on interleukin-1beta and tumor necrosis factor alpha signaling in human astroglial cells.
Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation.
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer.
Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.
Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.
Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock.
Enhanced IkappaB kinase activity is responsible for the augmented activity of NF-kappaB in human head and neck carcinoma cells.
Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation.
Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression.
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa B signaling, stimulated by Escherichia coli O157:H7 in Vero cells.
Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis.
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I.
Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG.
Experimental study on early protective effect of ischemic preconditioning on rat kidney graft.
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas.
Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.
Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients.
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.
Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice.
Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor kappaB.
FoxO: linking new signaling pathways.
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements.
G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses.
Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.
Gain-of-Function Mutations in the Toll-Like Receptor Pathway: TPL2-Mediated ERK1/ERK2 MAPK Activation, a Path to Tumorigenesis in Lymphoid Neoplasms?
Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.
Gene transfer of inhibitor kappaB in human lung cancer cell line NCI-H460 inhibits tumorigenesis and angiogenesis in vivo.
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Genetic instability in Hodgkin's lymphoma.
Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB.
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis.
Growth Inhibition and Apoptosis Induction by Tumor Necrosis Factor-alpha in Human Urethral Rhabdosphincter Satellite Cells.
Hepatitis B Virus Polymerase Suppresses NF-?B Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90?.
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase.
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.
Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha.
Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity.
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.
Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
HSP72 protects against obesity-induced insulin resistance.
HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit.
Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo.
Human chorionic gonadotropin decreases proliferation and invasion of breast cancer MCF-7 cells by inhibiting NF-kappaB and AP-1 activation.
Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.
Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells.
Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase.
Hyperoxia prolongs tumor necrosis factor-alpha-mediated activation of NF-kappaB: role of IkappaB kinase.
I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively.
Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter.
Identification of a Ligand-induced Transient Refractory Period in Nuclear Factor-{kappa}B Signaling.
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.
Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells.
Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.
Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-?B-independent and ERK-dependent pathway.
IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines.
IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.
IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells.
IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells.
IkappaB kinase is an essential component of the Tpl2 signaling pathway.
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis.
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy.
IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium.
IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway.
IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas.
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells.
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.
IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.
IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
IKK-beta inhibitors: an analysis of drug-receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches.
IKK1/2 protect human cells from TNF-mediated RIPK1-dependent apoptosis in an NF-?B-independent manner.
IKK? inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line.
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.
IKKalpha at the crossroads of inflammation and metastasis.
IKKalpha controls formation of the epidermis independently of NF-kappaB.
IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia.
IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells.
IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex.
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers.
Immunohistochemical study of the ubiquitin-nuclear factor-kB pathway in the endometrium of the baboon (Papio anubis) with and without endometriosis.
In adenovirus type 12 tumorigenic cells, major histocompatibility complex class I transcription shutoff is overcome by induction of NF-kappaB and relief of COUP-TFII repression.
In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination.
In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline Involvement of caspase cascades and IkappaBalpha phosphorylation.
Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells.
Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma.
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors.
Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling.
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.
Inflammation-activated protein kinases as targets for drug development.
Inflammatory mechanisms contributing to pancreatic cancer development.
Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.
Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin.
Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor.
Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives.
Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells.
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis.
Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids.
Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.
Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival.
Inhibition of NF-kappaB activation by merlin.
Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner.
Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers.
Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells.
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Inhibition of TBK1 reduces choroidal neovascularization in vitro and in vivo.
Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo.
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B).
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis.
Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota.
Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation.
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Ischemic preconditioning improves rat kidney allograft function after ischemia/reperfusion injury: the role of tumor necrosis factor-alpha.
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes.
Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation.
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation.
Limb and skin abnormalities in mice lacking IKKalpha.
Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells.
Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms.
Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis.
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis.
Lymphotoxin-beta receptor activation by lymphotoxin-alpha(1)beta(2) and LIGHT promotes tumor growth in an NFkappaB-dependent manner.
Lymphotoxin-beta receptor mediates NEMO-independent NF-kappaB activation.
Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.
Mathematical model of NF-kappaB regulatory module.
Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.
Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells.
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.
Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB.
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF-?B pathway.
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Modification of cysteine-179 of IkappaBalpha kinase by Nimbolide leads to downregulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Modification of IkappaBalpha by taurine bromamine inhibits tumor necrosis factor alpha-induced NF-kappaB activation.
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling.
Mutational analysis of IkappaBalpha in hematologic malignancies.
Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.
Mutations of NFKBIA in biopsy specimens from Hodgkin lymphoma.
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.
N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.
NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
NF-?B inhibition protects against tumor-induced cardiac atrophy in vivo.
NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors.
NF-kappaB activation: nondegradative ubiquitination implicates NEMO.
NF-kappaB and IKK as therapeutic targets in cancer.
NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.
NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells.
NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.
NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7.
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
NF-kappaB: a stress-regulated switch for cell survival.
NF-kappaB: linking inflammation and immunity to cancer development and progression.
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.
Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.
Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA.
Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer.
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.
Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.
Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression.
Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.
Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex.
Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis.
Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway.
Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha.
Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition.
Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis.
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide.
Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.
Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha.
Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta.
Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice.
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Preventive effect of a proteasome inhibitor on the formation of accelerated atherosclerosis in rabbits with uremia.
Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies.
Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha.
Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress.
Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.
Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha.
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.
Purified human plasma glycosaminoglycans reduced NF-kappaB activation, pro-inflammatory cytokine production and apoptosis in LPS-treated chondrocytes.
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta.
Ras-related GTPase Rhob represses NF-kappaB signaling.
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
Reduced Skeletal Muscle Inhibitor of {kappa}B{beta} Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Regulation and function of IKK and IKK-related kinases.
Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB.
Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1.
Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer.
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells.
Regulation of NF-{kappa}B responses by epigenetic suppression of I{kappa}B{alpha} expression in HCT116 intestinal epithelial cells.
Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells.
RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.
RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts.
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration.
Requirement of NEMO/IKK? for effective expansion of KRAS-induced precancerous lesions in the pancreas.
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.
Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells.
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo.
Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex.
Role of K63-linked polyubiquitination in NF-?B signalling: which ligase catalyzes and what molecule is targeted?
Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].
Roles for the IKK-Related Kinases TBK1 and IKK? in Cancer.
RSK2 mediates NF-{kappa}B activity through the phosphorylation of I{kappa}B{alpha} in the TNF-R1 pathway.
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation.
Short-term modulation of interleukin-1beta signaling by hyperoxia: uncoupling of IkappaB kinase activation and NF-kappaB-dependent gene expression.
Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Signaling by the Mpl receptor involves IKK and NF-kappaB.
Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
Single injection of naked plasmid encoding alpha-melanocyte-stimulating hormone protects against thioacetamide-induced acute liver failure in mice.
Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.
Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.
Specific IKKbeta inhibitor IV blocks streptonigrin-induced NF-kappaB activity and potentiates its cytotoxic effect on cancer cells.
Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.
Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta.
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.
Suppression of tumour necrosis factor-alpha by Schizonepeta tenuifolia water extract via inhibition of IkappaBalpha degradation and Jun N-terminal kinase/stress-activated protein kinase activation.
Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells.
Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth.
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.
Targeted repression of overexpressed CD30 downregulates NF-kappaB and ERK1/2 pathway in Hodgkin lymphoma cell lines.
Targeting Autophagic Regulation of NFkappaB in HTLV-I Transformed Cells by Geldanamycin: Implications for Therapeutic Interventions.
Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.
Targeting TANK-binding kinase 1 (TBK1) in cancer.
Targeting the PIAS1 SUMO ligase pathway to control inflammation.
Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis.
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.
The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalpha.
The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-kappa B).
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
The Ectodysplasin and NFkappaB signalling pathways in odontogenesis.
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.
The IkappaB kinase - a bridge between inflammation and cancer.
The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions.
The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice.
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation.
The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.
The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.
The possible correlation between activation of NF-kappaB/IkappaB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis.
The Prosurvival IKK-Related Kinase IKK? Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.
The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model.
The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity.
The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
The Specific IKK?/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-?B and MAP Kinase Pathways.
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.
The transcription factor nuclear factor-kappa B and cancer.
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Theaflavin, a black tea extract, is a novel anti-inflammatory compound.
Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity.
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK).
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.
Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1.
Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell.
Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation.
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses.
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells.
Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel.
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.
Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor".
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.
Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts.
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.
Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions.
Ubiquitin activated tumor necrosis factor receptor associated factor-6 (TRAF6) is recycled via deubiquitination.
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.
Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells.
Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
[Effect and significance of anisodamine on IkappaB kinase-beta in Kupffer cells following hemorrhagic shock]
[Effect of Berberine on the Insulin Resistance and TLR4/IKKbeta/NF-kappaB Signaling Pathways in Skeletal Muscle of Obese Rats with Insulin Resistance].
[Expression of nuclear transcription factor kappaB in hamster buccal pouch carcinogenesis]
[Human pathologies associated with NF-kappaB defects]
[Lipopolysaccaride influenced peritoneal mesothelial cells on the growth and expression of tumor necrosis factor through nuclear factor kappaB pathway]
[The alternative NF-kB activation pathway and cancer: friend or foe?]
[The role of NF-kappaB in colon cancer].
Nephritis
T-lymphocyte-specific knockout of IKK-2 or NEMO induces Th17 cells in an experimental nephrotoxic nephritis mouse model.
Nephrotic Syndrome
Transcriptional and post-transcriptional alterations of IkappaBalpha in active minimal-change nephrotic syndrome.
[Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic syndrome]
Neuralgia
Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice.
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
The role of spinal nuclear factor-kappa B in spinal hyperexcitability.
Neuroblastoma
Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells.
Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells.
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells.
Neurodegenerative Diseases
alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation.
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders.
Specific correction of a splice defect in brain by nutritional supplementation.
Neuroinflammatory Diseases
G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses.
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates ?-Synuclein Gene-induced Neurodegeneration.
LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation.
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity.
Newcastle Disease
Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK{epsilon}
Non-alcoholic Fatty Liver Disease
Animal models of steatohepatitis.
IkappaB kinase epsilon: a potential therapeutic target for obesity (and nonalcoholic fatty liver disease)?
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Obesity
Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body insulin sensitivity.
Defective hypothalamic autophagy directs the central pathogenesis of obesity via IKK-beta/NF-kappaB pathway.
Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK? for the treatment of obesity.
Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner.
Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains.
High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity.
Human Protein Kinases and Obesity.
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
IkappaB kinase epsilon: a potential therapeutic target for obesity (and nonalcoholic fatty liver disease)?
IKKepsilon: a bridge between obesity and inflammation.
Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor.
JNK1 and IKK{beta}: molecular links between obesity and metabolic dysfunction.
Mechanisms of obesity and related pathology: linking immune responses to metabolic stress.
Molecular mechanism of interactions between Chrysin and I-kappa-B kinase epsilon (IKKe)/Tank Binding Kinase-1(TBK1): Cell based assay and insilico molecular docking studies.
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
The protein kinase IKKepsilon regulates energy balance in obese mice.
Osteoarthritis
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.
Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
Biochemical and Computational Studies of the Interaction between a Glucosamine Derivative, NAPA, and the IKK? Kinase.
Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.
Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes.
Osteolysis
IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis.
Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis.
Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis.
The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.
Osteosarcoma
Okadaic acid induces tyrosine phosphorylation of IkappaBalpha that mediated by PKR pathway in human osteoblastic MG63 cells.
Ovarian Neoplasms
Activation of NF-{kappa}B Signaling by Inhibitor of NF-{kappa}B Kinase {beta} Increases Aggressiveness of Ovarian Cancer.
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.
Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer.
IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines.
MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma.
Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis.
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells.
[Effect of topotecan on expression of aquaporin protein 5 and nuclear factor-kappaB in ovarian cancer SKOV3 cells.]
Overnutrition
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system.
Pancreatic Neoplasms
Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model.
Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor.
Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.
Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.
NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.
Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor-{kappa}B in Cancer Cells: Delineation of a Novel Pathway.
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.
Pancreatitis
Hyperbaric oxygen reduces inflammatory response in acute pancreatitis by inhibiting NF-kappaB activation.
Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells.
Papilloma
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Parasitic Diseases
Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei.
Parkinson Disease
A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.
Analysis of ?-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease.
Autophagy and innate immunity: Insights from invertebrate model organisms.
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
Clinical heterogeneity of the LRRK2 G2019S mutation.
Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.
Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.
Discovery of Highly Potent, Selective and Brain Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors.
Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease.
Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes.
Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.
Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker.
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Inhibitors of LRRK2 kinase activity to probe the treatment option in Parkinson's disease.
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.
Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs.
LRRK2 Ablation Attenuates ?lpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.
Lrrk2 and Lewy body disease.
LRRK2 and the Endolysosomal System in Parkinson's Disease.
LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.
LRRK2 kinase in Parkinson's disease.
LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?
LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson's Disease and Other Neurodegenerative Disorders.
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.
Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.
Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach.
Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease.
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756).
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.
Role of LRRK2 kinase dysfunction in Parkinson disease.
Small-Molecule Inhibitors of LRRK2.
The development of CNS-active LRRK2 inhibitors using property-directed optimisation.
The development of inhibitors of leucine-rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play.
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.
The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.
Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease.
Parkinsonian Disorders
Lrrk2 and Lewy body disease.
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
Persistent Infection
Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei.
Photosensitivity Disorders
Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin.
Pituitary Neoplasms
Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pneumonia
A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.
Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway.
Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia.
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.
Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.
Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats.
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation.
Porcine Reproductive and Respiratory Syndrome
Autophagy and innate immunity: Insights from invertebrate model organisms.
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond.
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Pre-Eclampsia
Pregnancy is associated with suppression of the nuclear factor kappaB/IkappaB activation pathway in peripheral blood mononuclear cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively.
Premature Birth
Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective I-kappaB kinase (IKK) inhibitors.
Prion Diseases
Prion propagation in mice lacking central nervous system NF-kappaB signalling.
Prostatic Neoplasms
A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells.
Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis.
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen.
Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor.
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers.
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo.
Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells.
NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Over-expression of IkappaB-kinase-epsilon (IKKepsilon/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines.
Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha.
Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer.
Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor".
[Curcumin-induced the expression of inhibitor kappaBalpha protein in human prostate cancer cells]
Proteinuria
Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis.
Pterygium
The Nuclear-Factor Kappa B Pathway is Activated in Pterygium.
Pulmonary Disease, Chronic Obstructive
Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease.
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.
Atrophy and hypertrophy signaling in the diaphragm of patients with COPD.
Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD).
Decreased exercise-induced expression of NF-{kappa}B regulated genes in muscle of COPD patients.
IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.
Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.
[The function of nuclear factor-erythroid 2-related factor 2 and its association with I-kappa B kinases alpha/beta in a rat model of chronic obstructive pulmonary disease.]
Pulmonary Edema
Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway.
Pulmonary Fibrosis
A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.
[Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats]
Reoviridae Infections
Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.
Reperfusion Injury
Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury.
IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury.
Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response.
Respiratory Distress Syndrome
Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome.
Respiratory Syncytial Virus Infections
IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.
Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells.
Retinoblastoma
Mechanisms by Which S-Albuterol Induces Human Bronchial Smooth Muscle Cell Proliferation.
Redox-mediated gene therapies for environmental injury: approaches and concepts.
Rhinitis, Allergic
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice.
Rocky Mountain Spotted Fever
NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha.
Rotavirus Infections
Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation.
Salivary Gland Neoplasms
5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells.
Salmonella Infections
beta-Catenin activity negatively regulates bacteria-induced inflammation.
Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor.
Sarcoma
Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
Sarcoma, Kaposi
Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Seizures
Nuclear factor-kappaB regulates seizure threshold and gene transcription following convulsant stimulation.
Sepsis
Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis.
Inhibition of LPS-induced NFkappaB activation by a glucan ligand involves down-regulation of IKKbeta kinase activity and altered phosphorylation and degradation of IkappaBalpha.
NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance.
Paeoniflorin Inhibits Systemic Inflammation and Improves Survival in Experimental Sepsis.
Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis.
Severe Fever with Thrombocytopenia Syndrome
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Shock, Septic
Attenuation of NF-kappaB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes.
Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter.
IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells.
Sjogren's Syndrome
Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter.
Skin Abnormalities
Limb and skin abnormalities in mice lacking IKKalpha.
Skin Diseases
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
IKKbeta Leads to an Inflammatory Skin Disease Resembling Interface Dermatitis.
Skin Neoplasms
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.
Spinal Cord Injuries
Inhibition of peripheral NF-kappaB activation by central action of alpha-melanocyte-stimulating hormone.
Spondylitis, Ankylosing
Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-?B Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains.
IkBalpha promoter polymorphisms in patients with ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
Curcumin Treatment Suppresses IKK{beta} Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study.
CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex.
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas.
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.
SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB.
Starvation
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Status Epilepticus
Nuclear factor-kappaB regulates seizure threshold and gene transcription following convulsant stimulation.
Stomach Neoplasms
5-Fluorouracil inhibits nitric oxide production through the inactivation of IkappaB kinase in stomach cancer cells.
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells.
Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells.
IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese.
Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer.
Superinfection
Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway.
Synucleinopathies
LRRK2 kinase regulates ?-synuclein propagation via RAB35 phosphorylation.
Thrombocytopenia
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Thyroid Neoplasms
Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells.
Trichuriasis
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Tuberculosis
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Urinary Bladder Neoplasms
Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression.
TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling.
Uterine Cervical Neoplasms
Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.
Vaccinia
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.
Inhibition of IkappaB Kinase by Vaccinia Virus Virulence Factor B14.
Mapping the i{kappa}B kinase beta (ikk{beta})-binding interface of B14, a vaccinia virus inhibitor of IKK{beta}-mediated activation of nuclear factor kappa B.
Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.
Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor kappa B activation.
The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation.
Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
Vascular Diseases
Feed-forward Signaling of TNF{alpha} and NF{kappa}B via IKK{beta} Pathway contributes to Insulin Resistance and Coronary Arteriolar Dysfunction in Type 2 Diabetic Mice.
Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation.
Vascular System Injuries
Peptide-based inhibition of I?B kinase/nuclear factor-?B pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes.
The NFkappaB inhibitory peptide, IkappaBalpha, prevents human vascular smooth muscle proliferation.
Vasculitis
I kappa B alpha promoter polymorphisms in patients with systemic lupus erythematosus.
Vesicular Stomatitis
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Autophagy and innate immunity: Insights from invertebrate model organisms.
FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions.
HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Viremia
The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1.
Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
Virus Diseases
Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase.
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein m013.
Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection.
IkappaB kinase beta (IKKbeta/IKK2/IKBKB)-A key molecule in signaling to the transcription factor NF-kappaB.
IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.
IkappaB-mediated inhibition of virus-induced beta interferon transcription.
Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.
Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein.
Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection.
Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
JNK2 and IKKbeta are required for activating the innate response to viral infection.
KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Molecular cloning of IKKbeta from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection.
MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.
Predicting and validating a model of suppressor of IKKepsilon through biophysical characterization.
Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK{epsilon}
Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.
Role of cyclophilin B in activation of interferon regulatory factor-3.
TANK-binding kinase 1 as a novel therapeutic target for viral diseases.
The Role of Herpes Simplex Virus Type 1 ?34.5 in the Regulation of IRF3 Signaling.
The Role of Optineurin in Antiviral Type I Interferon Production.
The role of the IKK complex in viral infections.
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
The transcription factor nuclear factor-kappa B and cancer.
Triggering the interferon antiviral response through an IKK-related pathway.
Ubiquitin-regulated recruitment of IKK{epsilon} to MAVS interferon signaling adapter.
USE OF THE PHARMACOLOGICAL INHIBITOR BX795 TO STUDY THE REGULATION AND PHYSIOLOGICAL ROLES OF TBK1 AND IKK{varepsilon}: A DISTINCT UPSTREAM KINASE MEDIATES SER172 PHOSPHORYLATION AND ACTIVATION.
Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis.
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
[Research progress on the role of TANK-binding kinase 1 in anti-virus innate immune response].
Whooping Cough
Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression.
Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses.
Yellow Fever
Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine.