Literature summary for 2.7.11.10 extracted from

Kwon, Y.; Choi, S.K.; Byeon, S.; Lee, Y.H.
Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone (2018), Lab. Invest., 98, 1311-1319 .

Search for more literature for 2.7.11.10

Inhibitors

Inhibitors	Comment	Organism	Structure
SC-514	i.e. 4-amino-[2,3'-bithiophene]-5-carboxamide	Rattus norvegicus
TPCA-1	i.e. 5-[(4-fluorophenyl)-2-ureido]thiophene-3-carboxamide	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [MYPT1]	Rattus norvegicus	the enzyme phosphorylates MYPT1 at Thr853	ADP + [MYPT1 phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q9QY78	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	mesenteric artery	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [MYPT1]	the enzyme phosphorylates MYPT1 at Thr853	Rattus norvegicus	ADP + [MYPT1 phosphoprotein]	-	?

Synonyms

Synonyms	Comment	Organism
IKK2	-	Rattus norvegicus
inhibitor kappa B kinase 2	-	Rattus norvegicus

General Information

General Information	Comment	Organism
metabolism	inhibitor kappa B kinase 2 plays an essential role in the activation of nuclear factor kappa B	Rattus norvegicus
physiological function	inhibitor kappa B kinase 2 is involved in the vascular contraction through regulation of myosin light chain phosphatase activity by phosphorylating MYPT1 at Thr853 in rat mesenteric arteries	Rattus norvegicus

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Release 2023.1 (January 2023)