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Literature summary for 2.7.11.10 extracted from

  • Amici, C.; Belardo, G.; Rozera, C.; Bernasconi, D.; Santoro, M.G.
    Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK) (2004), Aids, 18, 1271-1280.
    View publication on PubMed
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
additional information herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells Homo sapiens

Application

Application Comment Organism
pharmacology enzyme is a target for development of inhibitors of HIV-1 replication, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
15d-prostaglandin J2 strongly inhibits IKK Homo sapiens
cyclopentenone prostanoids inhibition of IKK and thus inhibition of NFkappaB-mediated HSV-1-induced HIV-1 replication Homo sapiens
prostaglandin 2alpha inhibits IKK Homo sapiens
prostaglandin A1 strongly inhibits IKK Homo sapiens
Prostaglandin A2 strongly inhibits IKK Homo sapiens
prostaglandin E1 inhibits IKK Homo sapiens
prostaglandin E2 inhibits IKK Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ACH-2 cell chronically infected with HIV-1 Homo sapiens
-
H9 cell chronically infected with HIV-1 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
T-cell
-
 Homo sapiens
-
T-lymphoblastoid cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IKK
-
 Homo sapiens