Literature summary for 2.7.11.10 extracted from

Dan, H.C.; Cooper, M.J.; Cogswell, P.C.; Duncan, J.A.; Ting, J.P.; Baldwin, A.S.
Akt-dependent regulation of NF-[kappa]B is controlled by mTOR and Raptor in association with IKK (2008), Genes Dev., 22, 1490-1500.

Search for more literature for 2.7.11.10

Activating Compound

Activating Compound	Comment	Organism	Structure
mTOR	mTOR (mammalian target of rapamycin) controls phosphorylation of IkappaBalpha and p65/RelA as shown by knockdown of mTOR in PC3 cells. Furthermore, overexpression of mTOR stimulates IKK activity	Homo sapiens
raptor	raptor (mTOR associated protein) controls phosphorylation of IkappaBalpha and p65/RelA as shown by knockdown of raptor in PC3 cells	Homo sapiens

Application

Application	Comment	Organism
molecular biology	it is shown that mTOR and Raptor, through an Akt-dependent pathway, control NF-kappaB activity in PC3 prostate cancer cells both at the level of IkappaBalpha and RelA/p65 phosphorylation	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	siRNA-directed knockdown of Akt2 in PC3 cells leads to dissociation of IKKalpha from the mTOR (mammalian target of rapamycin) complex	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Rapamycin	suppresses IKK activity potentailly through dissociation of raptor from the mTOR complex; suppresses IKK activity potentailly through dissociation of raptor from the mTOR complex	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14920	-	-
Homo sapiens	O15111	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	knockdown of either mTOR or raptor in PC3 cells induces phosphorylation of IKKalpha and IKKbeta in their activation loops	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + IkappaBalpha	-	Homo sapiens	ADP + phosphorylated IkappaBalpha	-	?
ATP + p65/RelA	-	Homo sapiens	ADP + phosphorylated p65/RelA	-	?

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Homo sapiens
IKKbeta	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)