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Literature summary for 2.7.11.10 extracted from

  • Wang, L.C.; Okitsu, C.Y.; Zandi, E.
    Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK (2005), J. Biol. Chem., 280, 7634-7644.
    View publication on PubMed

Application

Application Comment Organism
medicine IKK activates TNFalpha-dependent signaling pathways inducing drug resistance, e.g. increasing cell survival in anti-cancer treatment with 5-fluoro-2'-deoxyuridine, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PS1145 inhibits IKK, blocks TNFalpha activation by IKK in vivo Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Colo-201 cell colon cancer cell line Homo sapiens
-
Colo-320 cell colon cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [GST-IkappaBalpha1-54 protein]
-
Homo sapiens ADP + [GST-IkappaBalpha1-54 phosphoprotein]
-
?
additional information IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IKK
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens