Application | Comment | Organism |
---|---|---|
medicine | IKK activates TNFalpha-dependent signaling pathways inducing drug resistance, e.g. increasing cell survival in anti-cancer treatment with 5-fluoro-2'-deoxyuridine, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PS1145 | inhibits IKK, blocks TNFalpha activation by IKK in vivo | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Colo-201 cell | colon cancer cell line | Homo sapiens | - |
Colo-320 cell | colon cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [GST-IkappaBalpha1-54 protein] | - |
Homo sapiens | ADP + [GST-IkappaBalpha1-54 phosphoprotein] | - |
? | |
additional information | IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |