Literature summary for 2.7.11.10 extracted from

Ishii, K.J.; Kawagoe, T.; Koyama, S.; Matsui, K.; Kumar, H.; Kawai, T.; Uematsu, S.; Takeuchi, O.; Takeshita, F.; Coban, C.; Akira, S.
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines (2008), Nature, 451, 725-729.

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Application

Application	Comment	Organism
medicine	TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	using TBK1-deficient mice it is shown by bone-marrow transfer experiments that TBK1-mediated signalling in haematopoietic cells is critical for the induction of antigen-specific B and CD41 T cells, whereas in non-haematopoietic cells TBK1 is required for CD81 T-cell induction	Mus musculus
additional information	using TBK1-deficient mice it is shown that TBK1 mediates the adjuvant effect of DNA vaccines and is essential for its immunogenicity in mice. Plasmid-DNA-activated, TBK1-dependent signalling and the resultant type-I interferon receptor-mediated signalling is required for induction of antigen-specific B and T cells, which occurred even in the absence of innate immune signalling through a well known CpG DNA sensorToll-like receptor 9 (TLR9) or Z-DNA binding protein 1	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	A1L361	-	-

Synonyms

Synonyms	Comment	Organism
TANK-binding kinase 1	-	Mus musculus
TBK1	-	Mus musculus

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Release 2023.1 (January 2023)