Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Bcl10 degradation depends on NEMO and CARMA1 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Bcl10 | Homo sapiens | negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview | ADP + phosphorylated Bcl10 | - |
? | |
ATP + IkappaBalpha | Homo sapiens | degradation of IkappaBalpha | ADP + phosphorylated IkappaBalpha | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Bcl | Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl | Homo sapiens | ADP + phosphorylated Bcl10 | - |
? | |
ATP + Bcl10 | negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview | Homo sapiens | ADP + phosphorylated Bcl10 | - |
? | |
ATP + IkappaBalpha | degradation of IkappaBalpha | Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
additional information | no activity with Rip2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase | - |
Homo sapiens |
IKKbeta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |