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Literature summary for 2.7.11.10 extracted from

  • Cao, Y.; Luo, J.L.; Karin, M.
    IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells (2007), Proc. Natl. Acad. Sci. USA, 104, 15852-15857.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Application

Application Comment Organism
medicine IKKlapha may represent a specific target for treatment of ErbB2-positive breast cancer Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information IkkalphaAA/AA 'knockin' mice, in which activation of IKKalpha is prevented by replacement of activation loop serines with alanines, exhibit delayed mammary gland growth during pregnancy, because IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, overview, retarded tumor development in response to either 7,12-dimethylbenzaanthracene or the ErbB2/Her2 transgene but had no effect on MMTV-v-Haras-induced cancer, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
breast
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 Mus musculus
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breast cancer cell
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 Mus musculus
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epithelium
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 Mus musculus
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mammary gland lobuloalveolar epithelial cell Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview Mus musculus ?
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Synonyms

Synonyms Comment Organism
IKKalpha
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 Mus musculus