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Literature summary for 2.7.11.10 extracted from
- Stimulus specificity of gene expression programs determined by temporal control of IKK activity (2005), Science, 309, 1857-1861.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | lipopolysaccharides stimulate cytokine-mediated IKK activity being positively feedback regulated | Mus musculus | |
| TNFalpha | induces IKK activity, activation is negatively feedback regulated | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | Mus musculus | inhibitor substrate is bound to NF-kappaB | ADP + [IkappaB phosphoprotein] | - |
? |  |
| additional information | Mus musculus | IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | embryonic fibroblast cell line | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [GST-IkappaBalpha1-54 protein] | - |
Mus musculus | ADP + [GST-IkappaBalpha1-54 phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | inhibitor substrate is bound to NF-kappaB | Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| additional information | IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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