Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | lipopolysaccharides stimulate cytokine-mediated IKK activity being positively feedback regulated | Mus musculus | |
TNFalpha | induces IKK activity, activation is negatively feedback regulated | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Mus musculus | inhibitor substrate is bound to NF-kappaB | ADP + [IkappaB phosphoprotein] | - |
? | |
additional information | Mus musculus | IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | embryonic fibroblast cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [GST-IkappaBalpha1-54 protein] | - |
Mus musculus | ADP + [GST-IkappaBalpha1-54 phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | inhibitor substrate is bound to NF-kappaB | Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
additional information | IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |