Literature summary for 2.7.11.10 extracted from

Anthony, N.G.; Baiget, J.; Berretta, G.; Boyd, M.; Breen, D.; Edwards, J.; Gamble, C.; Gray, A.I.; Harvey, A.L.; Hatziieremia, S.; Ho, K.H.; Huggan, J.K.; Lang, S.; Llona-Minguez, S.; Luo, J.L.; McIntosh, K.; Paul, A.; Plevin, R.J.; Robertson, M.N.; Scott, R.; Suckling, C.J.; Sutcliffe, O.B.; Young, L.C.; Mackey, S.P.
Inhibitory kappa B kinase alpha (IKKalpha) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers (2017), J. Med. Chem., 60, 7043-7066 .

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Inhibitors

Inhibitors	Comment	Organism
(1R,4R)-4-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanol	-	Homo sapiens
(R)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
(R)-2-amino-4-(3-hydroxypyrrolidin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
(S)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
1-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-sulfonamide	-	Homo sapiens
2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide	-	Homo sapiens
2-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide	-	Homo sapiens
2-amino-4-((1R,2S,3R,4S)-2,3,4-trihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-((1R,4R)-4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-((1R,4R)-4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide	-	Homo sapiens
2-amino-4-((1RS,2SR,3RS)-2,3-dihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-((cyclopropylmethyl)amino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(2-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]- pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(2-hydroxyethylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(2-hydroxyphenyl)-77H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(2-morpholinoethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(3-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(3-hydroxypropylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(3-hydroyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-(2-hydroxyethyl)piperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-hydroxymethyl)phenyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimdine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(cyclohexyl(2-hydroxyethyl)amino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(cyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(cyclohexylmethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-morpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
2-amino-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	-	Homo sapiens
3-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimdin-4-yl)benzamide	-	Homo sapiens
3-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide	-	Homo sapiens
4-((2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-benzenesulfonamide	-	Homo sapiens
4-((2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-benzoic acid	-	Homo sapiens
4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimdin-4-yl)benzamide	-	Homo sapiens
4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide	-	Homo sapiens
4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(p-tolyl)-benzenesulfonamide	-	Homo sapiens
4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-methylbenzenesulfonamide	-	Homo sapiens
4-(2-amino-7H-pyrrol[2,3-d]pyrimidin-4-yl)benzenesulfonamide	-	Homo sapiens
4-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide	-	Homo sapiens
4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide	-	Homo sapiens
4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine	-	Homo sapiens
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine	-	Homo sapiens
N-(4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-methanesulfonamide	-	Homo sapiens
N4-cyclohexyl-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	-	Homo sapiens
N4-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	20 mM used in assay conditions	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [IkappaB protein]	Homo sapiens	-	ADP + [IkappaB phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14920	-	-
Homo sapiens	O15111	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
U2-OS cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [IkappaB protein]	-	Homo sapiens	ADP + [IkappaB phosphoprotein]	-	?

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Homo sapiens
IKKbeta	-	Homo sapiens
inhibitory kappa B kinase alpha	-	Homo sapiens
inhibitory kappa B kinase beta	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00008	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
0.0001	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-methylbenzenesulfonamide
0.0003	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.0004	-	at pH 7.5 and 30Â°C	Homo sapiens	N-(4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-methanesulfonamide
0.00061	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-7H-pyrrol[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.00065	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-hydroxymethyl)phenyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.0008	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1R,2S,3R,4S)-2,3,4-trihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.001	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1RS,2SR,3RS)-2,3-dihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.001	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
0.0014	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(p-tolyl)-benzenesulfonamide
0.0014	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-methylbenzenesulfonamide
0.0015	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.0016	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-hydroxyethylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0016	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimdine-5-carbonitrile
0.0017	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0017	-	at pH 7.5 and 30Â°C	Homo sapiens	N-(4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-methanesulfonamide
0.0018	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(cyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.002	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1R,4R)-4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.002	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0021	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.0023	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-hydroxymethyl)phenyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.0024	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-hydroyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0024	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.0025	-	at pH 7.5 and 30Â°C	Homo sapiens	(R)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0025	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.0029	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-7H-pyrrol[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.0031	-	at pH 7.5 and 30Â°C	Homo sapiens	(S)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0036	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1R,2S,3R,4S)-2,3,4-trihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0038	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-hydroyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.004	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.004	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0053	-	at pH 7.5 and 30Â°C	Homo sapiens	1-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-sulfonamide
0.0053	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0053	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0053	-	at pH 7.5 and 30Â°C	Homo sapiens	3-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
0.0059	-	at pH 7.5 and 30Â°C	Homo sapiens	1-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-sulfonamide
0.0059	-	at pH 7.5 and 30Â°C	Homo sapiens	3-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
0.006	-	at pH 7.5 and 30Â°C	Homo sapiens	(R)-2-amino-4-(3-hydroxypyrrolidin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.0077	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0098	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.01	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.01	-	at pH 7.5 and 30Â°C	Homo sapiens	4-((2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-benzenesulfonamide
0.0121	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-hydroxypropylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.013	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.013	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.015	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-hydroxyphenyl)-77H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.016	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((cyclopropylmethyl)amino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.016	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimdin-4-yl)benzamide
0.016	-	at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(p-tolyl)-benzenesulfonamide
0.02	-	at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimdine-5-carbonitrile
0.02	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-morpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	(1R,4R)-4-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanol
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	(R)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	(R)-2-amino-4-(3-hydroxypyrrolidin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	(S)-2-amino-4-(2-(hydroximethyl)pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1R,4R)-4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1R,4R)-4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((1RS,2SR,3RS)-2,3-dihydroxycyclopentylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-((cyclopropylmethyl)amino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]- pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-hydroxyethylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-hydroxyphenyl)-77H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(2-morpholinoethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(3-hydroxypropylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-(2-hydroxyethyl)piperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(cyclohexyl(2-hydroxyethyl)amino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(cyclohexylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(cyclohexylmethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-morpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	2-amino-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	3-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimdin-4-yl)benzamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-((2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-benzenesulfonamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-((2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-benzoic acid
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-(2-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimdin-4-yl)benzamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	N4-cyclohexyl-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.03	-	IC50 above 0.03 mM, at pH 7.5 and 30Â°C	Homo sapiens	N4-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine