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Literature summary for 2.7.11.10 extracted from

  • Chen, L.W.; Egan, L.; Li, Z.W.; Greten, F.R.; Kagnoff, M.F.; Karin, M.
    The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion (2003), Nat. Med., 9, 575-581.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information type 1 TNFalpha induces the enzyme activity Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information disruption of the gene encoding IKKbeta leads to apoptotic tissue damage, e.g. in mucosa, and prevention of systemic inflammatory response, which results in the multiple organ dysfunction syndrome MODS Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection ?
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?
additional information Mus musculus C57/BL6J activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BI/6J mice
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Mus musculus C57/BL6J
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C57BI/6J mice
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Source Tissue

Source Tissue Comment Organism Textmining
enterocyte
-
Mus musculus
-
intestinal mucosa
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus ?
-
?
additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
IKK
-
Mus musculus