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Literature summary for 2.7.11.10 extracted from

  • Aleksic, T.; Baumann, B.; Wagner, M.; Adler, G.; Wirth, T.; Weber, C.K.
    Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2 (2007), Gut, 56, 227-236.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
overexpression of a gain-of-function mutant of IKK2, IKK2-EE or IKK2CA, in transgenic mice pancreas using an inducible genetic tet system, the mice additionally overexpress CMV-rtTA protein, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
S177E/S181E site-directed mutagenesis, gain-of-function mutant of IKK2, IKK2-EE or IKK2CA, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus activated IKK2 is responsible for induction of leucocyte infiltration in pancreatic acini, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, the enzyme is involved in the proinflammatory IKK/NF-kappaB pathway, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
pancreas
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 Mus musculus
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pancreatic acinar cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activated IKK2 is responsible for induction of leucocyte infiltration in pancreatic acini, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, the enzyme is involved in the proinflammatory IKK/NF-kappaB pathway, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase-2
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 Mus musculus
IKK2
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 Mus musculus