Literature summary for 2.7.11.10 extracted from

Chen, R.; Alvero, A.B.; Silasi, D.A.; Kelly, M.G.; Fest, S.; Visintin, I.; Leiser, A.; Schwartz, P.E.; Rutherford, T.; Mor, G.
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells (2008), Oncogene, 27, 4712-4723.

Search for more literature for 2.7.11.10

Application

Application	Comment	Organism
molecular biology	regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	ectopic expression of IKKbeta in epithelial ovarian cancer cells (EOC) induces cytokine production in Type II EOC cells	Homo sapiens
S177E/S181E	ectopic overexpression of a constitutively active form of IKKbeta in Type II epithelial ovarian cancer cells (EOC) results in a significant decrease in IkappaBalpha expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14920	-	-
Homo sapiens	O15111	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Homo sapiens
phosphoprotein	treatment with TNF-alpha induces a time-dependent increase in phosphorylated IKKbeta in Type I EOC cells but not in Type II EOC cells. No changes are observed for IKKalpha in either cell type	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-2780 cell	-	Homo sapiens	-
A-2780 cell	microRNA hsa-miR-199a regulates IKKbeta expression in epithelial ovarian cancer cells (EOC)	Homo sapiens	-
additional information	a total of 20 primary epithelial ovarian cancer cells are used. The ratio of IKKbeta/IKKalpha expression is significantly higher in type I than type II cells	Homo sapiens	-
additional information	a total of 20 primary epithelial ovarian cancer cells are used. The ratio of IKKbeta/IKKalpha expression is significantly higher in type I than type II cells. MicroRNA hsa-miR-199a regulates IKKbeta expression in epithelial ovarian cancer cells (EOC)	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-
SKOV-3 cell	microRNA hsa-miR-199a regulates IKKbeta expression in epithelial ovarian cancer cells (EOC)	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Homo sapiens
IKKbeta	-	Homo sapiens

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Release 2023.1 (January 2023)