Literature summary for 2.7.11.10 extracted from

Olivotto, E.; Borzi, R.M.; Vitellozzi, R.; Pagani, S.; Facchini, A.; Battistelli, M.; Penzo, M.; Li, X.; Flamigni, F.; Li, J.; Falcieri, E.; Facchini, A.; Marcu, K.B.
Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes (2008), Arthritis Rheum., 58, 227-239.

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Application

Application	Comment	Organism
molecular biology	IKKalpha and IKKbeta exert differential roles in ECM remodeling and endochondral ossification, which are events characteristic of hypertrophic chondrocytes and also complicating factors often found in osteoarthritic chondrocytes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of IKKalpha or IKKbeta is ablated in primary human chondrocytes by retrotransduction of specific short-hairpin RNAs. Micromass cultures designed to reproduce chondrogenesis with progression to the terminal hypertrophic stage are established, and anabolism and remodeling of the extracellular matrix (ECM) are investigated in the micromasses. Ablation of IKKalpha dramatically enhance type II collagen deposition independent of SOX9 protein levels but in association with suppressed levels of runt-related transcription factor 2. IKKalpha-deficient cells retain the phenotype of cells in a pre-hypertrophic-like state, as evidenced by the smaller size and faster proliferation of these cells prior to micromass seeding, along with the enhanced viability of their differentiated micromasses	Homo sapiens
additional information	expression of IKKalpha or IKKbeta is ablated in primary human chondrocytes by retrotransduction of specific short-hairpin RNAs. Silencing of IKKbeta markedly enhances accumulation of glycosaminoglycan in conjunction with increased SOX9 expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14920	-	-
Homo sapiens	O15111	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Homo sapiens
IKKbeta	-	Homo sapiens

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Release 2023.1 (January 2023)