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Literature summary for 2.7.11.10 extracted from

  • Kinoshita, D.; Hirota, F.; Kaisho, T.; Kasai, M.; Izumi, K.; Bando, Y.; Mouri, Y.; Matsushima, A.; Niki, S.; Han, H.; Oshikawa, K.; Kuroda, N.; Maegawa, M.; Irahara, M.; Takeda, K.; Akira, S.; Matsumoto, M.
    Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance (2006), J. Immunol., 176, 3995-4002.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information generation of IKKalpha-/- mice, an autoimmune disease phenotype is induced in athymic nude mice by grafting embryonic thymus from IKKalpha-deficient mice Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKKalpha is involved in the noncanonical NF-kappaB activation pathway, and plays an essential role in thymic organogenesis required for the establishment of self-tolerance, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 BALB/cA Jcl-ny mice, BALB/cnu/nu mice, and NIKaly/aly mice
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium thymus Mus musculus
-
thymocyte
-
 Mus musculus
-
thymus stroma, embryonic Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKalpha is involved in the noncanonical NF-kappaB activation pathway, and plays an essential role in thymic organogenesis required for the establishment of self-tolerance, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IKKalpha
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus