Literature summary for 2.7.11.10 extracted from

Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M.
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation (1999), Science, 284, 309-313.

Search for more literature for 2.7.11.10

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a protein	Homo sapiens	phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses	ADP + a phosphoprotein	-	?
ATP + a protein	Mus musculus	phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses	ADP + a phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15111	-	-
Mus musculus	Q60680	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a protein	phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses	Homo sapiens	ADP + a phosphoprotein	-	?
ATP + a protein	phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses	Mus musculus	ADP + a phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
IkappaBalpha	-	Homo sapiens
inhibitor of nuclear factor kappa B kinase beta subunit inhibitor of nuclear factor kappa-B kinase alpha subunit	-	Homo sapiens
inhibitor of nuclear factor kappa-B kinase alpha subunit	-	Mus musculus

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Release 2023.1 (January 2023)