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Literature summary for 2.7.11.10 extracted from

  • Hayakawa, Y.; Maeda, S.; Nakagawa, H.; Hikiba, Y.; Shibata, W.; Sakamoto, K.; Yanai, A.; Hirata, Y.; Ogura, K.; Muto, S.; Itai, A.; Omata, M.
    Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis (2009), J. Gastroenterol., 44, 935-943.
    View publication on PubMed
Search for more literature for 2.7.11.10

Application

Application Comment Organism
medicine IKKbeta-targeted NF-kappaB blockade is an attractive therapeutic approach for the prevention of colitis-associated tumors Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
IMD-0354
-
 Mus musculus
NBD peptide NEMO-binding domain peptide Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Mus musculus
-
J-774.1 cell
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
MC-38 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?

Subunits

Subunits Comment Organism
heterotrimer IkappaB kinase, IKK, consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit IKKgamma, NEMO Mus musculus

Synonyms

Synonyms Comment Organism
IkappaB kinase beta
-
 Mus musculus
IKKbeta
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus