Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.10 extracted from

  • Mancino, A.; Habbeddine, M.; Johnson, E.; Luron, L.; Bebien, M.; Memet, S.; Fong, C.; Bajenoff, M.; Wu, X.; Karin, M.; Caamano, J.; Chi, H.; Seed, M.; Lawrence, T.
    I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection (2013), EMBO J., 32, 816-828.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Protein Variants

Protein Variants Comment Organism
additional information generation of knock-in mice that express a mutant form of IKKalpha that cannot be activated, i.e. IKKalphaAA Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IFN regulatory factor 3 protein] Mus musculus IRF3 activation is triggered by IKKepsilon/TBK1-mediated phosphorylation on Ser396 ADP + [IFN regulatory factor 3 phosphoprotein]
-
 ?
ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?
ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Mus musculus
-
dendritic cell
-
 Homo sapiens
-
fibroblast murine embryonic fibroblast, MEF Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IFN regulatory factor 3 protein (380-427)] the truncated mutant is a good substrate Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein (380-427)]
-
 ?
ATP + [IFN regulatory factor 3 protein] IRF3 activation is triggered by IKKepsilon/TBK1-mediated phosphorylation on Ser396 Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein]
-
 ?
ATP + [IFN regulatory factor 3 protein] phosphorylation on Ser396, and phosphorylation of Ser402/404/405 cluster in the C-terminal regulatory domain of IRF3 in vitro Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein]
-
 ?
ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?
ATP + [S386A IFN regulatory factor 3 protein] the mutant substrate is equally phosphorylated as the wild-type IRF3 Mus musculus ADP + [S386A IFN regulatory factor 3 phosphoprotein]
-
 ?
ATP + [S396A IFN regulatory factor 3 protein] the mutant substrate is equally phosphorylated as the wild-type IRF3 Mus musculus ADP + [S396A IFN regulatory factor 3 phosphoprotein]
-
 ?
ATP + [S402A/S404A/S405A IFN regulatory factor 3 protein] low activity with the IRF3 mutant Mus musculus ADP + [S402A/S404A/S405A IFN regulatory factor 3 phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
CHUK
-
 Mus musculus
CHUK
-
 Homo sapiens
I kappa B kinase alpha
-
 Mus musculus
I kappa B kinase alpha
-
 Homo sapiens
IKKalpha
-
 Mus musculus
IKKalpha
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism TAK1-mediated IKKalpha activation may regulate IRF3-dependent IFNbeta expression downstream of IKKepsilon/TBK1 activation in dendritic cells. IKKalpha-mediated phosphorylation of IRF3 promotes CBP recruitment and transcriptional activity Mus musculus
physiological function IKKalpha is required in dendritic cells for priming antigen-specific protective CD4+ and CD8+ T-cells, and acquired immunity to the human pathogen Listeria monocytogenes, role for IKKalpha in regulation of IFN regulatory factor 3, IRF3, activity and the functional maturation of dendritic cells. IKKalpha plays reciprocal roles in innate and adaptive immunity, limiting non-specific inflammation while promoting acquired antigen-specific immunity. Requirement for IKKalpha in lymphotoxin beta signalling in radiation-resistant stromal cells Homo sapiens
physiological function IKKalpha is required in dendritic cells for priming antigen-specific T cells, role for IKKalpha in regulation of IFN regulatory factor 3, IRF3, activity and the functional maturation of dendritic cells. Phosphorylation of the Ser402/404/405 cluster of residues is important for IRF3 activation and IFNbeta expression in response to viral infection. IKKalpha plays reciprocal roles in innate and adaptive immunity, limiting non-specific inflammation while promoting acquired antigen-specific immunity. IKKalpha activation in the haematopoietic compartment is critical for acquired immunity to the facultative intracellular pathogen Listeria monocytogenes. Requirement for IKKalpha in lymphotoxin beta signalling in radiation-resistant stromal cells Mus musculus