Information on EC 3.1.3.16 - protein-serine/threonine phosphatase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.3.16
-
RECOMMENDED NAME
GeneOntology No.
protein-serine/threonine phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
-
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SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9025-75-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
mollusc, phosphatase type 2C
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
strain 7600
Uniprot
Manually annotated by BRENDA team
strain 7600
Uniprot
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
marine dinoflagellate
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Mus musculus C57BL6
C57Bl6 mice
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-
Manually annotated by BRENDA team
pea
-
-
Manually annotated by BRENDA team
winged bean
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain AY925
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-
Manually annotated by BRENDA team
serovar Typhi, strains CT18 and Ty2
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-
Manually annotated by BRENDA team
strain MI200
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-
Manually annotated by BRENDA team
the wild type strain DSM 639 missing 322 bp called MW001
UniProt
Manually annotated by BRENDA team
the wild type strain DSM 639 missing 322 bp called MW001
UniProt
Manually annotated by BRENDA team
strain PCC 6803, genes sll1033 and sll1387 encoding SynPPM3 and SynPPP1
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
wheat
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-
Manually annotated by BRENDA team
strain SM 427
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Manually annotated by BRENDA team
cultivar Ile de France
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
14-3-3epsilon phosphoprotein + H2O
14-3-3epsilon protein + phosphate
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl methylphosphonate + H2O
4-nitrophenol + methylphosphonate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
4-nitrophenyl phosphate + H2O
nitrophenol + phosphate
show the reaction diagram
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
show the reaction diagram
a phosphoprotein + H2O
a protein + phosphate
show the reaction diagram
-
the enzyme is specific from serinel/threonine-phosphorylated proteins including casein, histone H2a, phosphorylase kinase, or glycogen phosphorylase. The enzyme does not display detectable protein phosphatase activity toward a number of tyrosine-phosphorylated substrates
-
-
?
a phosphoprotein + H2O
dephosphorylated protein + phosphate
show the reaction diagram
-
-
-
-
?
Ala-Arg-Thr-Cys-Arg-Ser-Gly-Ser(P)-Val-Tyr + H2O
Ala-Arg-Thr-Cys-Arg-Ser-Gly-Ser-Val-Tyr + phosphate
show the reaction diagram
-
best substrate
-
-
?
alpha-naphthyl phosphate + H2O
alpha-naphthol + phosphate
show the reaction diagram
-
-
-
-
?
beta-naphthyl phosphate + H2O
beta-naphthol + phosphate
show the reaction diagram
-
-
-
-
?
biotin-DGDFEEIPEE(P)YLQNH2 + H2O
biotin-DGDFEEIPEEYLQNH2 + phosphate
show the reaction diagram
-
-
-
-
?
carrier protein-p53-phosphoserine + H2O
carrier protein-p53-serine + phosphate
show the reaction diagram
-
-
-
-
?
carrier protein-PB1-phosphoserine + H2O
carrier protein-PB1-serine + phosphate
show the reaction diagram
-
-
-
-
?
carrier protein-T3-phosphothreonine + H2O
carrier protein-T3-threonine + phosphate
show the reaction diagram
carrier protein-T4-phosphothreonine + H2O
carrier protein-T4-threonine + phosphate
show the reaction diagram
carrier protein-T5-phosphothreonine + H2O
carrier protein-T5-threonine + phosphate
show the reaction diagram
-
-
-
-
?
chicken acidic leucine-rich epidermal growth factor-like domain-containing brain protein/neuroglycan C + H2O
?
show the reaction diagram
-
the regulatory subunit of protein phosphatase 2A, B56beta, interacts with chicken acidic leucine-rich epidermal growth factor-like domain-containing brain protein/neuroglycan C (CALEB/NGC) and inhibits CALEB/NGC-mediated dendritic branching but not spine formation
-
-
?
DADEpYLPQQG + H2O
DADEYLPQQG + phosphate
show the reaction diagram
DLDVPIPGRFDRRVS(P)VAAE + H2O
DLDVPIPGRFDRRVSVAAE + phosphate
show the reaction diagram
-
-
-
-
?
DLDVPIPGRFDRRVSVAAE + H2O
? + phosphate
show the reaction diagram
DLDVPIPGRFDRRVY(P)VAAE + H2O
DLDVPIPGRFDRRVYVAAE + phosphate
show the reaction diagram
-
-
-
-
?
DRRVS(P)VAAE + H2O
DRRVSVAAE + phosphate
show the reaction diagram
-
-
-
-
?
DRVY(P)IHPFHL + H2O
DRVYIHPFHL + phosphate
show the reaction diagram
-
-
-
-
?
ENDpYINASL + H2O
ENDYINASL + phosphate
show the reaction diagram
ETTYERW(pT)TITQRER + H2O
ETTYERWTTITQRER + phosphate
show the reaction diagram
-
-
-
?
FDRRVS(P)VAAE + H2O
FDRRVSVAAE + phosphate
show the reaction diagram
-
-
-
-
?
FLRT(P)SCG + H2O
FLRTSCG + phosphate
show the reaction diagram
-
-
-
-
?
FLRTS(P)CG + H2O
FLRTSCG + phosphate
show the reaction diagram
-
-
-
-
?
FLRTT(P)CG + H2O
FLRTTCG + phosphate
show the reaction diagram
-
-
-
-
?
fluorotyrosine phosphate + H2O
fluorotyrosine + phosphate
show the reaction diagram
-
-
-
-
?
fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O
fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + phosphate
show the reaction diagram
-
heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
-
-
?
FYDEEVDEMY(P)REAPIDKKGNFNY(P)VEFTR + H2O
FYDEEVDEMYREAPIDKKGNFNYVEFTR + phosphate
show the reaction diagram
-
-
-
-
?
glycogen synthase + H2O
glycogen synthase + phosphate
show the reaction diagram
glycogen synthase b + H2O
glycogen synthase I + phosphate
show the reaction diagram
glycogen synthase D + H2O
glycogen synthase I + phosphate
show the reaction diagram
histone + H2O
histone + phosphate
show the reaction diagram
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-
-
-
?
KRpTIRR + H2O
KRTIRR + phosphate
show the reaction diagram
KRpTIRR + H2O
KRTIRR phosphate
show the reaction diagram
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-
-
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?
myelin basic phosphoprotein + H2O
myelin basic protein + phosphate
show the reaction diagram
myelin basic protein + H2O
? + phosphate
show the reaction diagram
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-
-
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?
myosin light chain phosphate + H2O
myosin light chain + phosphate
show the reaction diagram
-
myosin light chain phosphatase is a specific form of PP1
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-
?
NIDAIRA(pS)LNIMSR + H2O
NIDAIRASLNIMSR + phosphate
show the reaction diagram
-
-
-
?
p-nitrophenyl phosphate + H2O
nitrophenol + phosphate
show the reaction diagram
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
p38 + H2O
?
show the reaction diagram
p38 MAP kinase phosphoprotein
?
show the reaction diagram
-
-
-
-
?
peptide mGluR3 + H2O
?
show the reaction diagram
-
-
-
?
Phe-Arg-Arg-Leu-Ser(P)-Ile-Ser + H2O
Phe-Arg-Arg-Leu-Ser-Ile-Ser + phosphate
show the reaction diagram
-
least effective substrate, corresponding to the alpha-subunit of protein phosphatase
-
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?
phosphatidylinositol-(3,4,5)-triphosphate + H2O
?
show the reaction diagram
the enzyme displays activity towards the D3 position of the phosphoinositide second messenger phosphatidylinositol (3,4,5)-triphosphate
-
-
?
phospho-Cdk2 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-Cdk6 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-D,L-tyrosine + H2O
D,L-tyrosine + phosphate
show the reaction diagram
-
-
-
-
?
phospho-L-serine + H2O
L-serine + phosphate
show the reaction diagram
-
-
-
-
?
phospho-L-threonine + H2O
L-threonine + phosphate
show the reaction diagram
-
-
-
-
?
phospho-L-tyrosine + H2O
L-tyrosine + phosphate
show the reaction diagram
phospho-MKK + H2O
MKK + phosphate
show the reaction diagram
-
-
-
-
?
phospho-PA3347 + H2O
PA3347 + phosphate
show the reaction diagram
-
dephosphorylation of Ser56 by PA3346
-
-
?
phospho-TAK1 + H2O
TAK1 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-threonylpeptide + H2O
threonylpeptide + phosphate
show the reaction diagram
-
-
-
-
?
phosphoangiotensin + H2O
angiotensin + phosphate
show the reaction diagram
-
phosphorylated at Tyr
-
-
?
phosphocasein + H2O
casein + phosphate
show the reaction diagram
phosphohistone + H2O
histone + phosphate
show the reaction diagram
phosphomyosin light chain + H2O
myosin light chain + phosphate
show the reaction diagram
phosphophosphorylase kinase + H2O
phosphorylase kinase + phosphate
show the reaction diagram
phosphoprotamine + H2O
protamine + phosphate
show the reaction diagram
phosphoprotein + H2O
protein + phosphate
show the reaction diagram
phosphoprotein K15F + H2O
protein K15F + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein R20A + H2O
protein R20A + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein RII + H2O
protein RII + phosphate
show the reaction diagram
-
-
-
-
?
phosphoproteins + H2O
proteins + phosphate
show the reaction diagram
phosphopyruvate kinase + H2O
pyruvate kinase + phosphate
show the reaction diagram
phosphorylase a + H2O
?
show the reaction diagram
-
-
-
-
?
phosphorylase a + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylase a + H2O
phosphorylase a + phosphate
show the reaction diagram
phosphorylase a + H2O
phosphorylase b + phosphate
show the reaction diagram
phosphorylated 3-hydroxy 3-methylglutaryl coenzyme A reductase + H2O
3-hydroxy 3-methylglutaryl coenzyme A reductase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated 80S-ribosome + H2O
80S-ribosome + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated acetyl-CoA carboxylase + H2O
acetyl-CoA carboxylase + phosphate
show the reaction diagram
-
i.e. EC 6.4.1.2, phosphorylated
-
-
?
phosphorylated AD P-Tau + H2O
AD P-Tau + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Akt protein + H2O
Akt protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Akt protein
-
?
phosphorylated Akt1 + H2O
Akt1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated alpha-casein + H2O
alpha-casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated alpha-subunit of eukaryotic peptide initiation factor 2 + H2O
alpha-subunit of eukaryotic peptide initiation factor + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated alpha-subunit of succinyl-CoA synthetase + H2O
alpha-subunit of succinyl-CoA synthetase + phosphate
show the reaction diagram
-
activity is lower than towards phosphorylated nucleoside-diphosphate kinase
-
-
?
phosphorylated androgen receptor + H2O
androgen receptor + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of androgen receptor
-
?
phosphorylated angiomotin + H2O
angiomotin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated AP-1/AP-2 + H2O
AP-1/AP-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of AP-1/AP-2
-
?
phosphorylated APC protein + H2O
APC protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of APC protein
-
?
phosphorylated apoptosis signal-regulating kinase 1 + H2O
apoptosis signal-regulating kinase 1 + phosphate
show the reaction diagram
phosphorylated ASK1 + H2O
ASK1 + phosphate
show the reaction diagram
-
ASK1 is inactivated by the isoform PP2Ceta
-
-
?
phosphorylated ataxia telangiectasia and Rad3-related + H2O
ataxia telangiectasia and Rad3-related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ataxia telangiectasia mutated kinase + H2O
ataxia telangiectasia mutated kinase + phosphate
show the reaction diagram
phosphorylated ATM and Rad 3 related kinase + H2O
ATM and Rad 3 related kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated ATM protein + H2O
ATM protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of ATM protein
-
?
phosphorylated atypical protein kinase C + H2O
atypical protein kinase C + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated aurora A + H2O
aurora A + phosphate
show the reaction diagram
phosphorylated axin + H2O
axin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of axin
-
?
phosphorylated B-catenin + H2O
B-catenin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of B-catenin
-
?
phosphorylated BAD protein + H2O
BAD protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of BAD protein
-
?
phosphorylated BAX protein + H2O
BAX protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of BAX protein
-
?
phosphorylated BCKDH complex + H2O
BCKDH complex + phosphate
show the reaction diagram
-
i.e. branched-chain alpha-keto acid dehydrogenase, phosphorylated
-
-
?
phosphorylated BCL-2 + H2O
BCL-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of BCL-2
-
?
phosphorylated Bcl2 + H2O
Bcl2 + phosphate
show the reaction diagram
-
PP2A-mediated dephosphorylation of Bcl2 promotes its direct interaction with p53 as well as a conformational change in Bcl2, PP2A directly interacts with the BH4 domain of Bcl2 as a docking site to potentially bridge PP2A to Bcl2's flexible loop domain containing the target serine 70 phosphorylation site
-
-
?
phosphorylated beta-catenin + H2O
beta-catenin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated brain proteins + H2O
brain proteins + phosphate
show the reaction diagram
-
e.g. DARPP-32, G-substrate, both phosphorylated at threonine, similar amino acid sequences and phosphorylation sites, protein K-F.
-
-
?
phosphorylated c-Jun N-terminal kinase + H2O
c-Jun N-terminal kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated c-MET + H2O
c-MET + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of c-MET
-
?
phosphorylated c-Myc + H2O
c-Myc + phosphate
show the reaction diagram
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O
Ca2+/calmodulin-dependent protein kinase II + phosphate
show the reaction diagram
phosphorylated CaBP4 + H2O
CaBP4 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated calmodulin-like domain of protein kinase + H2O
calmodulin-like domain of protein kinase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated calpain + H2O
calpain + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of calpain
-
?
phosphorylated CAM kinase IV + H2O
CAM kinase IV + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CAM kinase IV
-
?
phosphorylated cAMP-dependent protein kinase + H2O
cAMP-dependent protein kinase + phosphate
show the reaction diagram
phosphorylated carboxypeptidase D + H2O
carboxypeptidase D + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of carboxypeptidase D
-
?
phosphorylated CAS protein + H2O
CAS protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CAS protein
-
?
phosphorylated casein (PKA) + H2O
casein (PKA) + phosphate
show the reaction diagram
phosphorylated casein + H2O
casein + phosphate
show the reaction diagram
phosphorylated Cav1.2 + H2O
Cav1.2 + phosphate
show the reaction diagram
phosphorylated Cbp1 + H2o
Cbp1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Cdc25c + H2O
Cdc25c + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Cdc25c
-
?
phosphorylated Cdc6 protein + H2O
Cdc6 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Cdc6 protein
-
?
phosphorylated Cdk1 + H2O
Cdk1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated CFTRCXCR2 + H2O
CFTRCXCR2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CFTRCXCR2
-
?
phosphorylated chemotaxis protein CheA + H2O
chemotaxis protein CheA + phosphate
show the reaction diagram
-
activity is lower than towards phosphorylated nucleoside-diphosphate kinase
-
-
?
phosphorylated Chk1 + H2O
Chk1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Chk1 protein + H2O
Chk1 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Chk1 protein
-
?
phosphorylated Chk2 + H2O
Chk2 + phosphate
show the reaction diagram
phosphorylated cyclin G1 + H2O
cyclin G1 + phosphate
show the reaction diagram
-
the B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated
-
-
?
phosphorylated DARPP-32 + H2O
DARP-32 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of DARP-32
-
?
phosphorylated deoxycytidine kinase + H2O
deoxycytidine kinase + phosphate
show the reaction diagram
-
protein phosphatase 2A negatively regulates deoxycytidine kinase activity via Ser-74 dephosphorylation
-
-
?
phosphorylated DNA-dependent protein kinase + H2O
DNA-dependent protein kinase + phosphate
show the reaction diagram
phosphorylated DNA-protease K + H2O
DNA-protease K + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated doublecortin + H2O
doublecortin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated E-cadherin + H2O
E-cadherin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of E-cadherin
-
?
phosphorylated Ebola virus VP30 protein + H2O
Ebola virus VP30 protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ERK + H2O
ERK + phosphate
show the reaction diagram
phosphorylated ERK protein + H2O
ERK protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of ERK protein
-
?
phosphorylated ERK-2 + H2O
ERK-2 + phosphate
show the reaction diagram
phosphorylated ERK1 + H2O
ERK1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ERK2 + H2O
ERK2 + phosphate
show the reaction diagram
phosphorylated ERK5 + H2O
ERK5 + phosphate
show the reaction diagram
-
dephosphorylation at Thr218 and Tyr220 residues, dephosphorylation site sequences, overview
-
-
?
phosphorylated estrogen receptor A + H2O
estrogen receptor A + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of estrogen receptor A
-
?
phosphorylated extracellular-signal-regulated kinase + H2O
extracellular-signal-regulated kinase + phosphate
show the reaction diagram
-
PP2A is involved in the inactivation, but not the activation, of extracellular-signal-regulated kinase
-
-
?
phosphorylated glucocorticoid receptor-heat shock protein 90 + H2O
glucocorticoid receptor-heat shock protein 90 + phosphate
show the reaction diagram
-
-
-
?
phosphorylated glycogen phosphorylase + H2O
glycogen phosphorylase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated glycogen phosphorylase a + H2O
glycogen phosphorylase a + phosphate
show the reaction diagram
phosphorylated glycogen phosphorylase alpha + H2O
glycogen phosphorylase alpha + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Gp130 protein + H2O
Gp130 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Gp130 protein
-
?
phosphorylated GSK3beta + H2O
GSK3beta + phosphate
show the reaction diagram
laforin dephosphorylates the inhibitory Ser9 of GSK3beta
-
-
?
phosphorylated H2AX + H2O
H2AX + phosphate
show the reaction diagram
phosphorylated HAND-1 + H2O
HAND-1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HAND-1
-
?
phosphorylated HAND-2 + H2O
HAND-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HAND-2
-
?
phosphorylated HDAC4 + H2O
HDAC4 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HDAC4
-
?
phosphorylated High mobility group box 1 protein + H2O
High mobility group box 1 protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated histone + H2O
histone + phosphate
show the reaction diagram
phosphorylated histone 2A member X + H2O
histone 2A member X + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated histone deacetylase 3 + H2O
histone deacetylase 3 + phosphate
show the reaction diagram
phosphorylated histone deacetylase 7 + H2O
histone deacetylase 7 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated histone h1 (PKA) + H2O
histone h1 (PKA) + phosphate
show the reaction diagram
phosphorylated histone h1 (PKC) + H2O
histone h1 (PKC) + phosphate
show the reaction diagram
phosphorylated histone H3 + H2O
histone H3 + phosphate
show the reaction diagram
-
dephosphorylation of histone H3 at Ser10 by PP1 is required for DNA methylation of some loci
-
-
?
phosphorylated histone IIA + H2O
histone IIA + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated hormone-sensitive lipase + H2O
hormone-sensitive lipase + phosphate
show the reaction diagram
phosphorylated Hsp90 + H2O
Hsp90 + phosphate
show the reaction diagram
-
PP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses
-
-
?
phosphorylated IkappaB kinase + H2O
IkappaB kinase + phosphate
show the reaction diagram
phosphorylated IKKB + H2O
IKKB + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of IKKB
-
?
phosphorylated IKKB protein + H2O
IKKB protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of IKKB protein
-
?
phosphorylated ILK1 + H2O
ILK1 + phosphate
show the reaction diagram
phosphorylated INAD-protein + H2O
INAD-protein + phosphate
show the reaction diagram
phosphorylated inhibitor-1 + H2O
inhibitor-1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated inhibitor-2 + H2O
inhibitor-2 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated JNK protein + H2O
JNK protein + phosphate
show the reaction diagram
phosphorylated JNK1 + H2O
JNK1 + phosphate
show the reaction diagram
-
dephosphorylation at Thr183 and Tyr185 residues, dephosphorylation site sequences, overview
-
-
?
phosphorylated katanin p60 + H2O
katanin p60 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated keratin 8 + H2O
keratin 8 + phosphate
show the reaction diagram
-
dephosphorylates at phospho-Ser431
-
-
?
phosphorylated KSR protein + H2O
KSR protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of KSR protein
-
?
phosphorylated lamban + H2O
lamban + phosphate
show the reaction diagram
phosphorylated Mdm2 protein + H2O
Mdm2 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Mdm2 protein
-
?
phosphorylated MEK3 + H2O
MEK3 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of MEK3
-
?
phosphorylated MEKK3 + H2O
MEKK3 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of MEKK3
-
?
phosphorylated messenger ribonucleoprotein + H2O
messenger ribonucleoprotein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated microtubule associated protein + H2O
microtubule associated protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Mid1 + H2O
Mid1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Mih1 + H2O
Mih1 + phosphate
show the reaction diagram
-
protein phosphatase 2A associated with Cdc55 dephosphorylates Mih1
-
-
?
phosphorylated mitogen-activated protein kinase kinase 3 + H2O
mitogen-activated protein kinase kinase 3 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated mitogen-activated protein kinase Pmk1p + H2O
mitogen-activated protein kinase Pmk1p + phosphate
show the reaction diagram
phosphorylated MKK3b + H2O
MKK3b + phosphate
show the reaction diagram
-
MKK3b is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated MKK4 + H2O
MKK4 + phosphate
show the reaction diagram
phosphorylated MKK6b + H2O
MKK6b + phosphate
show the reaction diagram
-
MKK6b is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated MKK7 + H2O
MKK7 + phosphate
show the reaction diagram
-
MKK7 is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated mouse double minute 2 homologue + H2O
mouse double minute 2 homologue + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated myelin basic protein + H2O
?
show the reaction diagram
-
-
-
-
?
phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
phosphorylated myosin light chain + H2O
myosin light chain + phosphate
show the reaction diagram
phosphorylated myosin light chain 2 + H2O
myosin light chain 2 + phosphate
show the reaction diagram
-
preferred target substrate for PP1 in the thick filament
-
-
?
phosphorylated myosin light chain peptide + H2O
myosin light chain peptide + phosphate
show the reaction diagram
-
KAKTTKKRPQRATSNVFS
-
-
?
phosphorylated NDEL1 + H2O
NDEL1 + phosphate
show the reaction diagram
-
PP4c selectively dephosphorylates NDEL1 at T219
-
-
?
phosphorylated nemo protein + H2O
nemo protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of nemo protein
-
?
phosphorylated nucleoside-diphosphate kinase + H2O
nucleoside-diphosphate kinase + phosphate
show the reaction diagram
phosphorylated nucleotide diphosphate kinase 2 + H2O
nucleotide diphosphate kinase 2 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated occludin + H2O
occludin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of occludin
-
?
phosphorylated P107 + H2O
P107 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of P107
-
?
phosphorylated p38 + H2O
p38 + phosphate
show the reaction diagram
phosphorylated p38alpha + H2O
p38alpha + phosphate
show the reaction diagram
phosphorylated p53 + H2O
p53 + phosphate
show the reaction diagram
phosphorylated p53 protein + H2O
p53 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of p53 protein
-
?
phosphorylated p53-binding protein 1 + H2O
p53-binding protein 1 + phosphate
show the reaction diagram
-
p53-binding protein 1 is dephosphorylated at Ser25 and Ser1778
-
-
?
phosphorylated PACS-1 + H2O
PACS-1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PACS-1
-
?
phosphorylated Par-3 + H2O
Par-3 + phosphate
show the reaction diagram
-
predominantly the alpha-isoform of PP1 binds phosphorylated Par-3 and specifically dephosphorylates at Ser-144 and Ser-824
-
-
?
phosphorylated Par-6 + H2O
Par-6 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated paxillin + H2O
paxillin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of paxillin
-
?
phosphorylated penicillin-binding protein + H2O
penicillin-binding protein + phosphate
show the reaction diagram
phosphorylated peptide + H2O
peptide + phosphate
show the reaction diagram
-
PP2Cdelta prefers the dephosphorylation at diphosphorylated T(P)X(P)Y sequence compared to monophosphorylated T(P)XY sequence
-
-
?
phosphorylated period + H2O
period + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of period
-
?
phosphorylated phosphoenolpyruvate carboxylase + H2O
phosphoenolpyruvate carboxylase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated phosphorylase a + H2O
phosphorylase a + phosphate
show the reaction diagram
phosphorylated phosphorylase alpha + H2O
phosphorylase alpha + phosphate
show the reaction diagram
phosphorylated phosphorylase kinase + H2O
phosphorylase kinase + phosphate
show the reaction diagram
phosphorylated phytochrome A + H2O
phytochrome A + phosphate
show the reaction diagram
-
PAPP2C dephosphorylates both native oat phytochrome A and a point mutant of S598A, whereas an N-terminal deletion of 65 amino acids prevents dephosphorylation
-
-
?
phosphorylated phytochrome B + H2O
phytochrome B + phosphate
show the reaction diagram
-
phytochrome B is autophosphorylated, the N-terminal extension-deleted phytochrome B shows no apparent autophosphorylation activity
-
-
?
phosphorylated PIM protein + H2O
PIM protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PIM protein
-
?
phosphorylated PKCbeta II + H2O
PKBbeta II + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PKCbeta II
-
?
phosphorylated PKCdelta + H2O
PKCdelta + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PKCdelta
-
?
phosphorylated Polo-like kinase 1 + H2O
Polo-like kinase 1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated pRb protein + H2O
pRb protein + phosphate
show the reaction diagram
phosphorylated protein kinase CK2alpha + H2O
protein kinase CK2alpha + phosphate
show the reaction diagram
-
-
-
?
phosphorylated protein kinase Hs11 + H2O
protein kinase Hs11 + phosphate
show the reaction diagram
phosphorylated protein phosphatase inhibitor-1 + H2O
protein phosphatase inhibitor-1 + phosphate
show the reaction diagram
phosphorylated Prz1 + H2o
Prz1 + phosphate
show the reaction diagram
phosphorylated pyruvate dehydrogenase + H2O
pyruvate dehydrogenase + phosphate
show the reaction diagram
phosphorylated Raf + H2O
Raf + phosphate
show the reaction diagram
-
Raf is dephosphorylated at Ser259
-
-
?
phosphorylated Raf-1 kinase + H2O
Raf 1 kinase + phosphate
show the reaction diagram
phosphorylated Raf1 + H2O
Raf-1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Raf1 + H2O
Raf1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Raf1
-
?
phosphorylated RalA + H2O
RalA + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of RalA
-
?
phosphorylated RelA + H2O
RelA + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of RelA
-
?
phosphorylated retinoblastoma protein + H2O
retinoblastoma protein + phosphate
show the reaction diagram
phosphorylated rhodopsin + H2O
rhodopsin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated RNA polymerase II + H2O
RNA polymerase II + phosphate
show the reaction diagram
phosphorylated SCR protein + H2O
SCR protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of SCR protein
-
?
phosphorylated securin + H2O
securin + phosphate
show the reaction diagram
phosphorylated Ser/Thr protein kinase + H2O
DNA-dependent Ser/Thr protein kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated seratonin + H2O
seratonin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of seratonin
-
?
phosphorylated serine-phosphorylated glycogen phosphorylase + H2O
glycogen phosphorylase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated serine/threonine protein kinase + H2O
serine/threonine protein kinase + phosphate
show the reaction diagram
phosphorylated Shc protein + H2O
Shc protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Shc protein
-
?
phosphorylated Sp1 + H2O
Sp1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Sp1
-
?
phosphorylated spliceosome-associated protein 155 + H2O
spliceosome-associated protein 155 + phosphate
show the reaction diagram
phosphorylated sprouty + H2O
sprouty + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of sprouty
-
?
phosphorylated Src protein + H2O
Src protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Src protein
-
?
phosphorylated stress-activated protein kinase + H2O
stress-activated protein kinase + phosphate
show the reaction diagram
phosphorylated TAK1-binding protein 1 + H2O
TAK1-binding protein 1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Tau + H2O
Tau + phosphate
show the reaction diagram
-
the Balpha regulatory subunit of PP2A facilitates dephosphorylation of the phosphorylated Tau
-
-
?
phosphorylated tau protein + H2O
tau protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of tau protein
-
?
phosphorylated tau-factor + H2O
tau-factor + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Tcn1/Crz1 + H2O
Tcn1/Crz1 + phosphate
show the reaction diagram
phosphorylated threonine-phosphorylated lipocortin I + H2O
lipocortin I + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated TRAF2 + H2O
TRAF2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of TRAF2
-
?
phosphorylated transforming growth factor beta-activated kinase 1 + H2O
transforming growth factor beta-activated kinase 1 + phosphate
show the reaction diagram
-
dephosphorylates Thr-187 in the TAK1 activation loop
-
-
?
phosphorylated transforming growth factor-beta-activated kinase 1 + H2O
transforming growth factor-beta-activated kinase 1 + phosphate
show the reaction diagram
phosphorylated tropomyosin-related kinase A + H2O
tropomyosin-related kinase A + phosphate
show the reaction diagram
-
two neuron-enriched regulatory subunits, B'beta and B'delta, recruit PP2A into a complex with tropomyosin-related kinase A to dephosphorylate the nerve growth factor receptor on Ser/Thr residues and to potentiate its intrinsic tyrosine kinase activity
-
-
?
phosphorylated troponin + H2O
troponin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated troponin I + H2O
troponin I + phosphate
show the reaction diagram
-
preferred target substrate for PP1 in the thin filament
-
-
?
phosphorylated troponin T + H2O
troponin T + phosphate
show the reaction diagram
-
preferred target substrate for PP1 in the thin filament
-
-
?
phosphorylated tumor suppressor protein p53 + H2O
tumor suppressor protein p53 + phosphate
show the reaction diagram
-
dephosphorylation at Thr55
-
-
?
phosphorylated UNG2 + H2O
UNG2 + phosphate
show the reaction diagram
-
dephosphorylation at Thr residues, identification of dephosphorylation site sequences, overview
-
-
?
phosphorylated vimentin + H2O
vimentin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of vimentin
-
?
phosphoserine-casein + H2O
casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphoserine-myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphoserine-RCML + H2O
RCML + phosphate
show the reaction diagram
-
i.e. reduced carboxyamidomethylated and maleylated lysozyme containing phosphoserine
-
-
?
phosphospectrin + H2O
spectrin + phosphate
show the reaction diagram
-
-
-
-
?
phosphothreonine + H2O
threonine + phosphate
show the reaction diagram
-
-
-
?
phosphotyrosine-casein + H2O
casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphotyrosine-myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphotyrosine-RCML + H2O
RCML + phosphate
show the reaction diagram
-
i.e. reduced carboxyamidomethylated and maleylated lysozyme containing phosphotyrosine
-
-
?
PIPGRFDRRVS(P)VAAE + H2O
PIPGRFDRRVSVAAE + phosphate
show the reaction diagram
-
-
-
-
?
Rad53p + H2O
?
show the reaction diagram
Raf proto-oncogene serine/threonine protein kinase + H2O
dephosporylated Raf proto-oncogene serine/threonine protein kinase + phosphate
show the reaction diagram
PP5 plays a role in the inactivation of Raf proto-oncogene serine/threonine protein kinase, PP5/Raf proto-oncogene serine/threonine protein kinase association occurs in response to growth factor stimulation and results in the selective dephosphorylation of Ser338, removing phosphate from this critical site that helps to maintain Raf proto-oncogene serine/threonine protein kinase activation
-
-
?
RAT(P)VA + H2O
RATVA + phosphate
show the reaction diagram
-
-
-
-
?
RII peptide + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
RRA(pT)VA + H2O
RRATVA + phosphate
show the reaction diagram
RRApSVA + H2O
?
show the reaction diagram
RRApTVA + H2O
?
show the reaction diagram
RRApTVA + H2O
RRATVA + phosphate
show the reaction diagram
RRAS(P)VA + H2O
RRASVA + phosphate
show the reaction diagram
RRAT(P)VA + H2O
RRATVA + phosphate
show the reaction diagram
RRLIEDAEY(P)AARG + H2O
RRLIEDAEYAARG + phosphate
show the reaction diagram
-
synthetic substrate
-
-
?
RRREEET(P)EE + H2O
RRREEETEE + phosphate
show the reaction diagram
-
-
-
-
?
serine/threonine-phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
-
-
-
-
?
SSpSLESLQTAVAEVTLNGNIPFHRPR + H2O
SSSLESLQTAVAEVTLNGNIPFHRPR + phosphate
show the reaction diagram
-
-
-
-
?
synthetic peptides with phosphotyrosyl residues + H2O
synthetic peptides + phosphate
show the reaction diagram
tetrafluorotyrosine phosphate + H2O
tetrafluorotyrosine + phosphate
show the reaction diagram
-
-
-
-
?
tumor necrosis factor receptor-associated factor 6 + H2O
?
show the reaction diagram
-
PP4 negatively regulates lipopolysaccharide-induced and tumor necrosis factor receptor-associated factor 6-mediated nuclear factor-kappaB activation by inhibiting the ubiquitination of tumor necrosis factor receptor-associated factor 6, PP4 is a negative feedback regulator of lipopolysaccharide/toll-like receptor 4 pathway
-
-
?
tyrosine-phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
-
-
-
-
?
tyrosine-phosphorylated sEGF-R + H2O
phosphorylated sEGF-R + phosphate
show the reaction diagram
-
-
-
-
?
UNC-89 + H2O
?
show the reaction diagram
-
the protein kinase 2 region of UNC-89 specifically interacts with SCPL-1
-
-
?
vasodilator associated phosphoprotein + H2O
vasodilator associated protein + phosphate
show the reaction diagram
-
-
-
-
?
[a peptide]-serine/threonine phosphate + H2O
[a peptide]-serine/threonine + phosphate
show the reaction diagram
[protein]-L-serine phosphate + H2O
[protein]-L-serine + phosphate
show the reaction diagram
[protein]-L-threonine phosphate + H2O
[protein]-L-threonine + phosphate
show the reaction diagram
-
-
-
?
additional information
?
-