Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Drosophila melanogaster | 31966 | - |
mitochondrial membrane | - |
Caenorhabditis elegans | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GST-tagged PGAM5 does not dephosphorylate phospho-Tyr peptides (like END-pYINASL or DADEpYLIPQQG) | Drosophila melanogaster | ? | - |
? | |
additional information | GST-tagged PGAM5 does not dephosphorylate phospho-Tyr peptides (like END-pYINASL or DADEpYLIPQQG) | Caenorhabditis elegans | ? | - |
? | |
p38 + H2O | - |
Drosophila melanogaster | ? | - |
? | |
p38 + H2O | - |
Caenorhabditis elegans | ? | - |
? | |
phosphorylated apoptosis signal-regulating kinase 1 + H2O | PGAM5 acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1 by dephosphorylation of inhibitory sites (phosphorylation of Thr-838), PGAM5 serves as a specialized activator of apoptosis signal-regulating kinase 1 | Drosophila melanogaster | apoptosis signal-regulating kinase 1 + phosphate | - |
? | |
phosphorylated apoptosis signal-regulating kinase 1 + H2O | PGAM5 acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1 by dephosphorylation of inhibitory sites (phosphorylation of Thr-838), PGAM5 serves as a specialized activator of apoptosis signal-regulating kinase 1 | Caenorhabditis elegans | apoptosis signal-regulating kinase 1 + phosphate | - |
? | |
RRApSVA + H2O | - |
Drosophila melanogaster | ? | - |
? | |
RRApSVA + H2O | - |
Caenorhabditis elegans | ? | - |
? | |
RRApTVA + H2O | - |
Drosophila melanogaster | ? | - |
? | |
RRApTVA + H2O | - |
Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGAM5 | - |
Drosophila melanogaster |
PGAM5 | - |
Caenorhabditis elegans |
phosphoglycerate mutase 5 | PGAM5 lacks PGAM activity and instead associates with signal-regulating kinase 1 and acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1, PGAM5 is a protein Ser/Thr phosphatase unrelated to the other known families of Ser/Thr phosphatases | Drosophila melanogaster |
phosphoglycerate mutase 5 | PGAM5 lacks PGAM activity and instead associates with signal-regulating kinase 1 and acts as a specific protein Ser/Thr phosphatase that activates apoptosis signal-regulating kinase 1, PGAM5 is a protein Ser/Thr phosphatase unrelated to the other known families of Ser/Thr phosphatases | Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | PGAM5 is an evolutionarily conserved activator of apoptosis signal-regulating kinase 1 | Drosophila melanogaster |
physiological function | PGAM5 is an evolutionarily conserved activator of apoptosis signal-regulating kinase 1 | Caenorhabditis elegans |