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Literature summary for 3.1.3.16 extracted from

  • Plummer, G.; Perreault, K.R.; Holmes, C.F.; Posse De Chaves, E.I.
    Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons (2005), Biochem. J., 385, 685-693.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
C6-ceramide activates in vivo and 2-3fold in vitro, blocked by protein phosphatase inhibitor-2, i.e. I-2, ceramide prevents retinoblastoma gene product pRb hyperphosphorylation by PP1 activation Rattus norvegicus
additional information nerve growth factor is required for PP activation in vivo Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by okadaic acid Rattus norvegicus
protein phosphatase inhibitor-2 i.e. I-2, specific for PP1 Rattus norvegicus
tautomycin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ceramide-induced cell survival mechanism, overview ?
-
 ?
phosphorylated pRb protein + H2O Rattus norvegicus ceramide prevents retinoblastoma gene product pRb protein hyperphosphorylation by PP1 activation, nerve growth factor deprivation in sympathetic neurons leads to inhibition of PP1 and hyperphosphorylation of pRb protein pRb protein + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron untreated and nerve growth factor-deprived sympathetic neurons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ceramide-induced cell survival mechanism, overview Rattus norvegicus ?
-
 ?
phosphorylated pRb protein + H2O
-
 Rattus norvegicus pRb protein + phosphate
-
 ?
phosphorylated pRb protein + H2O ceramide prevents retinoblastoma gene product pRb protein hyperphosphorylation by PP1 activation, nerve growth factor deprivation in sympathetic neurons leads to inhibition of PP1 and hyperphosphorylation of pRb protein Rattus norvegicus pRb protein + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP-1
-
 Rattus norvegicus
serine/threonine protein phosphatase-1
-
 Rattus norvegicus