Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.16 extracted from

  • Thaci, D.; Salgo, R.
    Malignancy concerns of topical calcineurin inhibitors for atopic dermatitis: facts and controversies (2010), Clin. Dermatol., 28, 52-56.
    View publication on PubMed
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
additional information the hypothetic mechanisms of carcinogenesis include a direct effect of calcineurin inhibitors on keratinocytes, because topical calcineurin inhibits DNA repair and reduces apoptosis in epidermal keratinocytes Homo sapiens
pimecrolimus a topical calcineurin inhibitor, treatement might bear high risk for skin cancer and lymphoma, overview Homo sapiens
tacrolimus a topical calcineurin inhibitor, treatment might bear high risk for skin cancer and lymphoma, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte epidermal Homo sapiens
-
lymphoma cell
-
 Homo sapiens
-
skin cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calcineurin
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function topical calcineurin inhibits DNA repair and reduces apoptosis in epidermal keratinocytes Homo sapiens