Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | an increase in PP5 protein levels is observed following prolonged hypoxia or treatment with reagents that induce oxidative stress | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y451A | okadaic acid insensitive mutant of PP5 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calyculin A | - |
Homo sapiens | |
cantharidin | - |
Homo sapiens | |
nodularin | - |
Homo sapiens | |
okadaic acid | - |
Homo sapiens | |
tautomycin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PP5 binds the A-subunit of the PP2A holoenzyme, which functions to tether the catalytic (PP2Ac) and substrate targeting B-subunits of PP2A | ? | - |
? | |
additional information | Homo sapiens | PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53041 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PP5 binds the A-subunit of the PP2A holoenzyme, which functions to tether the catalytic (PP2Ac) and substrate targeting B-subunits of PP2A | Homo sapiens | ? | - |
? | |
additional information | PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress | Homo sapiens | ? | - |
? | |
phosphorylated apoptosis signal-regulating kinase 1 + H2O | apoptosis signal-regulating kinase 1 is transiently activated by autophosphorylation at Thr845 | Homo sapiens | apoptosis signal-regulating kinase 1 + phosphate | - |
? | |
phosphorylated ataxia telangiectasia mutated kinase + H2O | - |
Homo sapiens | ataxia telangiectasia mutated kinase + phosphate | - |
? | |
phosphorylated ATM and Rad 3 related kinase + H2O | - |
Homo sapiens | ATM and Rad 3 related kinase + phosphate | - |
? | |
phosphorylated glucocorticoid receptor-heat shock protein 90 + H2O | - |
Homo sapiens | glucocorticoid receptor-heat shock protein 90 + phosphate | - |
? | |
phosphorylated Ser/Thr protein kinase + H2O | - |
Homo sapiens | DNA-dependent Ser/Thr protein kinase + phosphate | - |
? | |
Raf proto-oncogene serine/threonine protein kinase + H2O | PP5 plays a role in the inactivation of Raf proto-oncogene serine/threonine protein kinase, PP5/Raf proto-oncogene serine/threonine protein kinase association occurs in response to growth factor stimulation and results in the selective dephosphorylation of Ser338, removing phosphate from this critical site that helps to maintain Raf proto-oncogene serine/threonine protein kinase activation | Homo sapiens | dephosphorylated Raf proto-oncogene serine/threonine protein kinase + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP5 | the catalytic domain of PP5 was originally designated as PP3 | Homo sapiens |
serine/threonine protein phosphatase type 5 | - |
Homo sapiens |