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Literature summary for 3.1.3.16 extracted from

  • Chen, G.; Zhou, X.; Nicolaou, P.; Rodriguez, P.; Song, G.; Mitton, B.; Pathak, A.; Zachariah, A.; Fan, G.C.; Dorn, G.W.; Kranias, E.G.
    A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation (2008), FASEB J., 22, 1790-1796.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Protein phosphatase inhibitor-1 PPI-1, the effect of activated inhibitor-1 on regulation of protein phosphorylation is critical in the stimulatory effects of beta-agonists in the heart. The mutant G147D inhibitor-1 decreases PLN phosphorylation in response to beta-adrenergic activation. The G147D polymorphism in PPI-1 occurs exclusively in Afro-American populations, quantitation of the expressional levels of wild-type inhibitor-1 and G147D inhibitor-1, also in white subjects. Overexpression of inhibitor-1 or its variant does not alter the levels of the major regulatory proteins related to cardiac calcium homeostasis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated lamban + H2O Homo sapiens
-
 lamban + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated lamban + H2O
-
 Homo sapiens lamban + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PPI
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function opposing the protein kinase A axis are protein phosphatases that dephosphorylate regulatory proteins, e.g. ryanodine receptor and phospholamban in sarcoplasmic reticulum, troponin I and C-protein in the myofilaments, and the plasma membrane L-type calcium channel, and play an essential role in maintaining biochemical and functional phosphorylation homeostasis, overview Homo sapiens