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Literature summary for 3.1.3.16 extracted from

  • Gushiken, F.C.; Patel, V.; Liu, Y.; Pradhan, S.; Bergeron, A.L.; Peng, Y.; Vijayan, K.V.
    Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling (2008), J. Biol. Chem., 283, 12862-12869.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in bone marrow-derived murine megakaryocytes and HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calyculin A
-
Homo sapiens
additional information fibrinogen binding to alphaIIbbeta3 during platelet adhesion decreases integrin-associated PP2A activity Homo sapiens
okadaic acid
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer Homo sapiens
65000
-
1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP2Ac associates with the integrin alphaIIbbeta3 complex in platelets, the alphaIIb membrane proximal region containing the KVGFFKR sequence can support the direct interaction of PP2Ac ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP2Ac associates with the integrin alphaIIbbeta3 complex in platelets, the alphaIIb membrane proximal region containing the KVGFFKR sequence can support the direct interaction of PP2Ac Homo sapiens ?
-
?
vasodilator associated phosphoprotein + H2O
-
Homo sapiens vasodilator associated protein + phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer Homo sapiens

Synonyms

Synonyms Comment Organism
PP2A
-
Homo sapiens
PP2Ac catalytic subunit of protein phosphatase 2A Homo sapiens
protein phosphatase 2A
-
Homo sapiens