Cloned (Comment) | Organism |
---|---|
expressed in bone marrow-derived murine megakaryocytes and HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calyculin A | - |
Homo sapiens | |
additional information | fibrinogen binding to alphaIIbbeta3 during platelet adhesion decreases integrin-associated PP2A activity | Homo sapiens | |
okadaic acid | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer | Homo sapiens |
65000 | - |
1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PP2Ac associates with the integrin alphaIIbbeta3 complex in platelets, the alphaIIb membrane proximal region containing the KVGFFKR sequence can support the direct interaction of PP2Ac | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PP2Ac associates with the integrin alphaIIbbeta3 complex in platelets, the alphaIIb membrane proximal region containing the KVGFFKR sequence can support the direct interaction of PP2Ac | Homo sapiens | ? | - |
? | |
vasodilator associated phosphoprotein + H2O | - |
Homo sapiens | vasodilator associated protein + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 65000 + 1 * 36000, the PP2A holoenzyme consists of an about 36 kDa catalytic subunit C and an about 65 kDa structural subunit A that together form an AC core dimer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Homo sapiens |
PP2Ac | catalytic subunit of protein phosphatase 2A | Homo sapiens |
protein phosphatase 2A | - |
Homo sapiens |