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Literature summary for 3.1.3.16 extracted from

  • Wang, B.; Zhang, P.; Wei, Q.
    Recent progress on the structure of Ser/Thr protein phosphatases (2008), Sci. China C Life Sci., 51, 487-494.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calyculin A inhibitor of isozymes PP1 and PP2A Homo sapiens
Inhibitor-1 inhibitor of isozyme PP1 Homo sapiens
Inhibitor-2 inhibitor of isozyme PP1 Homo sapiens
microcystin-LR inhibitor of isozymes PP1 and PP2A Homo sapiens
additional information isozyme PP2 is insensitive to inhibitor-1 and inhibitor-2 Homo sapiens
okadaic acid inhibitor of isozymes PP1 and PP2A Homo sapiens
tautomycin inhibitor of isozymes PP1 and PP2A Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isozyme PP2B is dependent on Ca2+ Homo sapiens
Fe2+ isozyme PP1 contains one Fe2+ and isozyme PP2B contains one Fe2+ at the centre of the catalytic site Homo sapiens
Mn2+ isozyme PP2A contains two Mn2+ and isozyme PP1 contains one Mn2+ at the centre of the catalytic site Homo sapiens
Zn2+ isozyme PP2B contains one Zn2+ at the centre of the catalytic site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated phosphorylase kinase + H2O Homo sapiens isozyme PP1 preferentially dephosphorylates the beta-subunit of phosphorylase kinase, isozyme PP2 preferentially dephosphorylates the alpha-subunit of phosphorylase kinase phosphorylase kinase + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
Homo sapiens protein + phosphate
-
?
phosphorylated phosphorylase kinase + H2O isozyme PP1 preferentially dephosphorylates the beta-subunit of phosphorylase kinase, isozyme PP2 preferentially dephosphorylates the alpha-subunit of phosphorylase kinase Homo sapiens phosphorylase kinase + phosphate
-
?

Subunits

Subunits Comment Organism
heterodimer isozyme PP1 and isozyme PP2B Homo sapiens
heterotrimer the PP2A holoenzyme consists of a heterodimeric core enzyme, comprising a scaffolding subunit and a catalytic subunit, as well as a variable regulatory subunit Homo sapiens

Synonyms

Synonyms Comment Organism
PP1
-
Homo sapiens
PP2A
-
Homo sapiens
PP2B also known as calcineurin Homo sapiens
type-I phosphatase
-
Homo sapiens
type-II phosphatase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin isozyme PP2B is dependent on calmodulin Homo sapiens