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Literature summary for 3.1.3.16 extracted from

  • Harvey, B.P.; Banga, S.S.; Ozer, H.L.
    Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts (2004), J. Biol. Chem., 279, 24889-24898.
    View publication on PubMed
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
PPM1F, expression as GST-tagged enzyme, expression as HA-tagged or Myc-tagged enzyme in CHO-K1 cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O Homo sapiens dephosphorylation of the autophosphorylated Thr286, PPM1F negatively regulates the multifunctional Ca2+/calmodulin-dependent protein kinase II, e.g. reducing the phosphorylation of vimentin Ca2+/calmodulin-dependent protein kinase II + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast SV40-transformed Homo sapiens
-
HS-74 cell bone marrow stromal fibroblast cell line Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O dephosphorylation of the autophosphorylated Thr286, PPM1F negatively regulates the multifunctional Ca2+/calmodulin-dependent protein kinase II, e.g. reducing the phosphorylation of vimentin Homo sapiens Ca2+/calmodulin-dependent protein kinase II + phosphate
-
 ?
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O dephosphorylation of the autophosphorylated Thr286 leading to CaMKII inactivation in vitro, PPM1F interacts with multifunctional Ca2+/calmodulin-dependent protein kinase II involving multiple regions independently of the phosphatase activity, analysis overview Homo sapiens Ca2+/calmodulin-dependent protein kinase II + phosphate
-
 ?
phosphorylated casein + H2O
-
 Homo sapiens casein + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CaM kinase phosphatase
-
 Homo sapiens
PP2C phosphatase
-
 Homo sapiens
PPM1F
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23 30 assay at Homo sapiens