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Literature summary for 3.1.3.16 extracted from

  • Gentile, S.; Darden, T.; Erxleben, C.; Romeo, C.; Russo, A.; Martin, N.; Rossie, S.; Armstrong, D.L.
    Rac GTPase signaling through the PP5 protein phosphatase (2006), Proc. Natl. Acad. Sci. USA, 103, 5202-5206.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Rac-GTP stimualtion of PP5, molecular mechanism Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid inhibition of wild-type PP5, no inhibition of PP5 mutant 451A Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PP5 acts as an effector in Rac GTPase signalling via interaction of its N-terminal TPR domain with Rac-GTP, PP5 inhibition results in blockage of KCNH2 channel stimulation by thyroid hormone and by Rac in pituitary cells, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P53042
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Source Tissue

Source Tissue Comment Organism Textmining
GH4-C1 cell pituitary cell line Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP5 acts as an effector in Rac GTPase signalling via interaction of its N-terminal TPR domain with Rac-GTP, PP5 inhibition results in blockage of KCNH2 channel stimulation by thyroid hormone and by Rac in pituitary cells, overview Rattus norvegicus ?
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?

Subunits

Subunits Comment Organism
More PP5 contains an unique tetratricopeptide repeat TPR-containing N-termiinal regulatory domain, PP5-Rac-GTP docking and structure modeling using crystal structure PDB code 1A17 Rattus norvegicus

Synonyms

Synonyms Comment Organism
PP5
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Rattus norvegicus
PP5 protein phosphatase
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Rattus norvegicus
PPT
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Rattus norvegicus
protein phosphatase T
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Rattus norvegicus
protein serine/threonine phosphatase
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Rattus norvegicus