Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Rac-GTP | stimualtion of PP5, molecular mechanism | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
okadaic acid | inhibition of wild-type PP5, no inhibition of PP5 mutant 451A | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PP5 acts as an effector in Rac GTPase signalling via interaction of its N-terminal TPR domain with Rac-GTP, PP5 inhibition results in blockage of KCNH2 channel stimulation by thyroid hormone and by Rac in pituitary cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P53042 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GH4-C1 cell | pituitary cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PP5 acts as an effector in Rac GTPase signalling via interaction of its N-terminal TPR domain with Rac-GTP, PP5 inhibition results in blockage of KCNH2 channel stimulation by thyroid hormone and by Rac in pituitary cells, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PP5 contains an unique tetratricopeptide repeat TPR-containing N-termiinal regulatory domain, PP5-Rac-GTP docking and structure modeling using crystal structure PDB code 1A17 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PP5 | - |
Rattus norvegicus |
PP5 protein phosphatase | - |
Rattus norvegicus |
PPT | - |
Rattus norvegicus |
protein phosphatase T | - |
Rattus norvegicus |
protein serine/threonine phosphatase | - |
Rattus norvegicus |