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Literature summary for 3.1.3.16 extracted from

  • Tanuma, N.; Kim, S.E.; Beullens, M.; Tsubaki, Y.; Mitsuhashi, S.; Nomura, M.; Kawamura, T.; Isono, K.; Koseki, H.; Sato, M.; Bollen, M.; Kikuchi, K.; Shima, H.
    Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155) (2008), J. Biol. Chem., 283, 35805-35814.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
nuclear inhibitor of protein phosphatase-1 NIPP1 directs PP1 to dephosphorylate the U2 small nuclear ribonucleoprotein particle component, spliceosome-associated protein 155, Sap155 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PP1 overexpression compromises pre-mRNA splicing Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
C-terminally truncated nuclear inhibitor of protein phosphatase-1 C-terminally truncated NIPP1 forms a hyperactive holoenzyme with PP1, rendering PP1 minimally phosphorylated on an inhibitory site Homo sapiens
additional information phosphorylation by cyclin-dependent kinases lower PP1 activity in vitro and vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated spliceosome-associated protein 155 + H2O Homo sapiens i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component. nuclear inhibitor of PP1, i.e. NIPP1, a major PP1 interactor in the vertebrate nucleus, recruits PP1 to Sap155 spliceosome-associated protein 155 + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by cyclin-dependent kinases lower PP1 activity in vitro and vivo Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated spliceosome-associated protein 155 + H2O i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component. nuclear inhibitor of PP1, i.e. NIPP1, a major PP1 interactor in the vertebrate nucleus, recruits PP1 to Sap155 Homo sapiens spliceosome-associated protein 155 + phosphate
-
?
phosphorylated spliceosome-associated protein 155 + H2O i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component Homo sapiens spliceosome-associated protein 155 + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP1
-
Homo sapiens
protein phosphatase-1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PP1 phosphorylation is essential for proper cell cycle progression. NIPP1-associated PP1 regulates Sap155 phosphorylation, overview Homo sapiens