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Literature summary for 3.1.3.16 extracted from

  • Kasa, A.; Czikora, I.; Verin, A.D.; Gergely, P.; Csortos, C.
    Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells (2013), Microvasc. Res., 89, 86-94.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
fostriecin more selective inhibitor of PP2A Homo sapiens
okadaic acid specific inhibitor of PP2A Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoprotein + H2O Homo sapiens
-
 protein + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
human lung microvascular endothelial cell
-
 Homo sapiens
-
pulmonary artery endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?
phosphorylated beta-catenin + H2O
-
 Homo sapiens beta-catenin + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
protein phosphatase 2A
-
 Homo sapiens
Ser/Thr protein phosphatase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of protein phosphatase 2A results in changes in the organization of endothelial cell cytoskeleton as microtubule dissolution and actin re-arrangement are detected. Depletion of Balpha regulatory subunit of protein phosphatase 2A has similar effect on the cytoskeleton structure of the cells Homo sapiens
physiological function the enzyme plays a significant role in the maintenance of endothelial cell cytoskeleton and barrier function with special focus on the Balpha (regulatory) subunit of protein phosphatase 2A. The PP2A Balpha regulatory subunit associates with adherent junction proteins Homo sapiens