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Literature summary for 3.1.3.16 extracted from

  • Golden, T.; Aragon, I.V.; Rutland, B.; Tucker, J.A.; Shevde, L.A.; Samant, R.S.; Zhou, G.; Amable, L.; Skarra, D.; Honkanen, R.E.
    Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer (2008), Biochim. Biophys. Acta, 1782, 259-270.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell elevated levels of PP5 protein occur in human breast cancer and suggest that PP5 over-expression may aid tumor progression Homo sapiens
-
MCF-7 cell PP5 overexpression correlates with both an increase in the rate of proliferation and protection from cell death induced by oxidative stress, UVC-irradiation, adriamycin, and vinblastine, PP5 overexpression has no apparent effect on the sensitivity of MCF-7 cells to taxol or rapamycin Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP5
-
 Homo sapiens
protein phosphatase 5
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
 Homo sapiens