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Literature summary for 3.1.3.16 extracted from

  • Wilkerson, J.E.; Satriotomo, I.; Baker-Herman, T.L.; Watters, J.J.; Mitchell, G.S.
    Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia (2008), J. Neurosci., 28, 2949-2958.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid PP2A activity is dose-dependently decreased with okadaic acid with 15% inhibition at 0.05 nM, 55% inhibition at 0.5 nM, and 69% inhibition at 5 nM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PP2A activity is present in the cytosolic fraction Rattus norvegicus 5829
-
membrane PP2A activity is present in the membrane fraction Rattus norvegicus 16020
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nucleus PP1 exhibits strong nuclear staining, PP2A and PP5 are more diffusely expressed Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
motoneuron phrenic motoneuron Rattus norvegicus
-
spinal cord ventral cervical spinal cord Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RRApTVA + H2O
-
Rattus norvegicus RRATVA + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP2A
-
Rattus norvegicus
protein phosphatase 2A
-
Rattus norvegicus