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Literature summary for 3.1.3.16 extracted from

  • Stefansson, B.; Ohama, T.; Daugherty, A.E.; Brautigan, D.L.
    Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains (2008), Biochemistry, 47, 1442-1451.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa and HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
440000
-
the PP6 catalytic subunit, SAPS domain subunits PP6R1 and PP6R3, and ankyrin repeat subunit ARS-A are all detected by immunoblotting, showing copurification in complexes with apparent Mr values of above 440 kDa Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification by DEAE column chromatography and Superose 12 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
Homo sapiens protein + phosphate
-
?

Subunits

Subunits Comment Organism
heterotrimer composed of the PP6 catalytic subunit bound to a suppressor of initiation of transcription 4-associated protein domain scaffold subunit that associates with ankyrin repeat protein 28 Homo sapiens

Synonyms

Synonyms Comment Organism
PP6
-
Homo sapiens
PP6R1 regulatory subunit of protein phosphatase 6, PP6R1 acts as a scaffold with separate regions for binding to protein phosphatase 6 and to ankyrin repeat protein 28 Homo sapiens
protein phosphatase 6
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
Homo sapiens