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Literature summary for 3.1.3.16 extracted from

  • Kajino, T.; Ren, H.; Iemura, S.; Natsume, T.; Stefansson, B.; Brautigan, D.L.; Matsumoto, K.; Ninomiya-Tsuji, J.
    Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway (2006), J. Biol. Chem., 281, 39891-39896.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calyculin A
-
Homo sapiens
okadaic acid inhibition at 100 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
293 cell
-
Homo sapiens
-
293-IL-1RI cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated transforming growth factor beta-activated kinase 1 + H2O dephosphorylates Thr-187 in the TAK1 activation loop Homo sapiens transforming growth factor beta-activated kinase 1 + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP2C
-
Homo sapiens
PP6 a type 2A protein phosphatase Homo sapiens
protein phosphatase 6
-
Homo sapiens