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Literature summary for 3.1.3.16 extracted from

  • Peti, W.; Nairn, A.C.; Page, R.
    Structural basis for protein phosphatase 1 regulation and specificity (2013), FEBS J., 280, 596-611.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calyculin A
-
Homo sapiens
DARPP-32
-
Homo sapiens
Inhibitor-2
-
Homo sapiens
microcystin
-
Homo sapiens
nodularin
-
Homo sapiens
okadaic acid
-
Homo sapiens
tautomycin
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ the catalytic active site contains two Mn2+ ions, Mn2+-bound enzyme always exhibits the highest activity and stability Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38500
-
x * 38500, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoprotein + H2O Homo sapiens
-
protein + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P62136
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
Homo sapiens protein + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 38500, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
PP1
-
Homo sapiens
protein phosphatase 1
-
Homo sapiens
serine/threonine protein phosphatase 1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PP1 regulates diverse, essential cellular processes such as cell cycle progression, protein synthesis, muscle contraction, carbohydrate metabolism, transcription and neuronal signaling Homo sapiens