Reference on EC 3.4.22.36 - caspase-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens, Mus musculus
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Kahns, S.; Kalai, M.; Jakobsen, L.D.; Clark, B.F.; Vandenabeele, P.; Jensen, P.H.
Caspase-1 and caspase-8 cleave and inactivate cellular parkin
J. Biol. Chem.
278
23376-23380
2003
Homo sapiens
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (P29452), Mus musculus, Mus musculus C3H/An (P29452)
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
Flaws, J.A.; Kugu, K.; Trbovich, A.M.; Desanti, A.; Tilly, K.I.; Hirshfield, A.N.; Tilly, J.L.
Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
Endocrinology
136
5042-5053
1995
Rattus norvegicus (P43527)
Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J. Biol. Chem.
272
7223-7228
1997
Homo sapiens (P29466)
Pirhonen, J.; Sareneva, T.; Julkunen, I.; Matikainen, S.
Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation
Eur. J. Immunol.
31
726-733
2001
Homo sapiens
Bae, S.S.; Choi, J.H.; Oh, Y.S.; Perry, D.K.; Ryu, S.H.; Suh, P.G.
Proteolytic cleavage of epidermal growth factor receptor by caspases
FEBS Lett.
491
16-20
2001
Homo sapiens
Kisselev, A.F.; Garcia-Calvo, M.; Overkleeft, H.S.; Peterson, E.; Pennington, M.W.; Ploegh, H.L.; Thornberry, N.A.; Goldberg, A.L.
the caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
J. Biol. Chem.
278
35869-35877
2003
Homo sapiens
Fassy, F.; Krebs, O.; Rey, H.; Komara, B.; Gillard, C.; Capdevila, C.; Yea, C.; Faucheu, C.; Blanchet, A.M.; Miossec, C.; Diu-Hercend, A.
Enzymic activity of two caspases related to interleukin-1beta-converting enzyme
Eur. J. Biochem.
253
76-83
1998
Homo sapiens
Thornberry, N.A.; Bull, H.G.; Calaycay, J.R.; et al.
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
Nature
356
768-774
1992
Homo sapiens (P29466)
Cerretti, D.P.; Kozlosky, C.J.; Mosley, B.; et al.
Molecular cloning of the interleukin-1 beta converting enzyme
Science
256
97-100
1992
Homo sapiens (P29466), Homo sapiens
Walker, N.P.C.; Talanian, R.V.; Brady, K.D.; Dang, L.C.; et al.
Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer
Cell
78
343-352
1994
Homo sapiens (P29466)
Okamoto, Y.; Anan, H.; Nakai, E.; Morihira, K.; Yonetoku, Y.; Kurihara, H.; Sakashita, H.; Terai, Y.; Takeuchi, M.; Shibanuma, T.
Isomura, Y.: Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
Chem. Pharm. Bull.
47
11-21
1999
Homo sapiens (P29466)
Alnemri, E.S.; Fernandes-Alnemri, T.; Litwack, G.
Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities
J. Biol. Chem.
270
4312-4317
1995
Homo sapiens (P29466), Homo sapiens
Nett-Fiordalisi, M.A.; Cerretti, D.P.; Berson, D.R.; Gilbert, D.J.; Jenkins, N.A.; Copeland, N.G.; Black, R.A.; Chaplin, D.D.
Molecular cloning of the murine IL-1 beta converting enzyme cDNA
J. Immunol.
149
3254-3259
1992
Mus musculus (P29452), Mus musculus
Molineaux, S.M.; Casano, F.J.; Rolando, A.M.; et al.
Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme
Proc. Natl. Acad. Sci. USA
90
1809-1813
1993
Mus musculus (P29452), Mus musculus
Keane, K.M.; Giegel, D.A.; Lipinski, W.J.; Callahan, M.J.; Shivers, B.D.
Cloning, tissue expression and regulation of rat interleukin 1 beta converting enzyme
Cytokine
7
105-110
1995
Rattus norvegicus (P43527)
Muneta Y.; Shimoji Y.; Yokomizo Y.; Mori Y.
Molecular cloning of porcine interleukin-1beta converting enzyme and differential gene expression of IL-1beta converting enzyme, IL-1beta, and IL-18 in porcine alveolar macrophages
J. Interferon Cytokine Res.
19
1289-1296
1999
Sus scrofa (Q9N2I1), Sus scrofa
Wardlow, S.; Penha-Goncalves, M.N.; Argyle, D.J.; Onions, D.E.; Nicolson, L.
Nucleotide sequence of equine caspase-1 cDNA
DNA Seq.
10
133-137
1999
Equus caballus (Q9TV13), Equus caballus
Taylor, S.; Hanlon, L.; McGillivray, C.; Gault, E.A.; Argyle, D.J.; Onions, D.E.; Nicolson, L.
Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides
DNA Seq.
10
387-394
2000
Canis lupus familiaris (Q9MZV7), Canis lupus familiaris, Felis catus (Q9MZV6), Felis catus
Ahmad, M.; Srinivasula, S.M.; Wang, L.; Litwack, G.; Fernandes-Alnemric, T.; Alnemri, E.S.
Sppdoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35
J. Biol. Chem.
272
1421-1424
1997
Spodoptera frugiperda (P89116), Spodoptera frugiperda
Song, Z.; McCall, K.; Steller, H.
DCP-1, a Drosophila cell death protease essential for development
Science
275
536-540
1997
Drosophila melanogaster (O02002)
Young, J.L.; Sukhova, G.K.; Foster, D.; Kisiel, W.; Libby, P.; Schonbeck, U.
The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
J. Exp. Med.
191
1535-1544
2000
Homo sapiens
Shahripour, A.B.; Plummer, M.S.; Lunney, E.A.; Albrecht, H.P.; Hays, S.J.; Kostlan, C.R.; Sawyer, T.K.; Walker, N.P.; Brady, K.D.; Allen, H.J.; Talanian, R.V.; Wong, W.W.; Humblet, C.
Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1)
Bioorg. Med. Chem.
10
31-40
2002
Homo sapiens
Imeri, L.; Bianchi, S.; Opp, M.R.
Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide
Am. J. Physiol. Regul. Integr. Comp. Physiol.
291
R197-R204
2006
Rattus norvegicus
Vaisid, T.; Kosower, N.S.; Barnoy, S.
Caspase-1 activity is required for neuronal differentiation of PC12 cells: cross-talk between the caspase and calpain systems
Biochim. Biophys. Acta
1743
223-230
2005
Rattus norvegicus
Harter, W.G.; Albrect, H.; Brady, K.; Caprathe, B.; Dunbar, J.; Gilmore, J.; Hays, S.; Kostlan, C.R.; Lunney, B.; Walker, N.
The design and synthesis of sulfonamides as caspase-1 inhibitors
Bioorg. Med. Chem. Lett.
14
809-812
2004
Homo sapiens
Fahr, B.T.; OBrien, T.; Pham, P.; Waal, N.D.; Baskaran, S.; Raimundo, B.C.; Lam, J.W.; Sopko, M.M.; Purkey, H.E.; Romanowski, M.J.
Tethering identifies fragment that yields potent inhibitors of human caspase-1
Bioorg. Med. Chem. Lett.
16
559-562
2006
Homo sapiens
Guo, H.; Petrin, D.; Zhang, Y.; Bergeron, C.; Goodyer, C.G.; LeBlanc, A.C.
Caspase-1 activation of caspase-6 in human apoptotic neurons
Cell Death Differ.
13
285-292
2006
Homo sapiens
Thalappilly, S.; Sadasivam, S.; Radha, V.; Swarup, G.
Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
FEBS J.
273
2766-2778
2006
Homo sapiens
Raupach, B.; Peuschel, S.K.; Monack, D.M.; Zychlinsky, A.
Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar typhimurium infection
Infect. Immun.
74
4922-4926
2006
Mus musculus
Cordoba-Rodriguez, R.; Fang, H.; Lankford, C.S.; Frucht, D.M.
Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18
J. Biol. Chem.
279
20563-20566
2004
Mus musculus
Miao, E.A.; Alpuche-Aranda, C.M.; Dors, M.; Clark, A.E.; Bader, M.W.; Miller, S.I.; Aderem, A.
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
Nat. Immunol.
7
569-575
2006
Mus musculus
Sarkar, A.; Hall, M.W.; Exline, M.; Hart, J.; Knatz, N.; Gatson, N.T.; Wewers, M.D.
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
Am. J. Respir. Crit. Care Med.
174
1003-1010
2006
Mus musculus
Wang, Y.; O'Neil, S.V.; Wos, J.A.; Oppong, K.A.; Laufersweiler, M.C.; Soper, D.L.; Ellis, C.D.; Baize, M.W.; Fancher, A.N.; Lu, W.; Suchanek, M.K.; Wang, R.L.; Schwecke, W.P.; Cruze, C.A.; Buchalova, M.; Belkin, M.; De, B.; Demuth, T.P.
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg. Med. Chem.
15
1311-1322
2007
Homo sapiens, Rattus norvegicus
Soper, D.L.; Sheville, J.; ONeil, S.V.; Wang, Y.; Laufersweiler, M.C.; Oppong, K.A.; Wos, J.A.; Ellis, C.D.; Fancher, A.N.; Lu, W.; Suchanek, M.K.; Wang, R.L.; De, B.; Demuth, T.P.
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg. Med. Chem. Lett.
16
4233-4236
2006
Homo sapiens
Ellis, C.D.; Oppong, K.A.; Laufersweiler, M.C.; ONeil, S.V.; Soper, D.L.; Wang, Y.; Wos, J.A.; Fancher, A.N.; Lu, W.; Suchanek, M.K.; Wang, R.L.; De, B.; Demuth, T.P.
Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg. Med. Chem. Lett.
16
4728-4732
2006
Homo sapiens
Gurcel, L.; Abrami, L.; Girardin, S.; Tschopp, J.; van der Goot, F.G.
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Cell
126
1135-1145
2006
Homo sapiens
Keller, M.; Rueegg, A.; Werner, S.; Beer, H.D.
Active caspase-1 is a regulator of unconventional protein secretion
Cell
132
818-831
2008
Homo sapiens, Mus musculus
Muehlbauer, S.M.; Evering, T.H.; Bonuccelli, G.; Squires, R.C.; Ashton, A.W.; Porcelli, S.A.; Lisanti, M.P.; Brojatsch, J.
Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
Cell Cycle
6
758-766
2007
Mus musculus
Fink, S.L.; Cookson, B.T.
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
Cell. Microbiol.
8
1812-1825
2006
Mus musculus
Merkle, S.; Frantz, S.; Schoen, M.P.; Bauersachs, J.; Buitrago, M.; Frost, R.J.; Schmitteckert, E.M.; Lohse, M.J.; Engelhardt, S.
A role for caspase-1 in heart failure
Circ. Res.
100
645-653
2007
Mus musculus
Vincent, J.A.; Mohr, S.
Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
Diabetes
56
224-230
2007
Mus musculus
Adlbrecht, C.; Hoetzenecker, K.; Posch, M.; Steiner, S.; Kopp, C.; Hacker, S.; Auer, J.; Horvath, R.; Moser, B.; Roth, G.; Wolner, E.; Lang, I.M.; Ankersmit, H.J.
Elevated levels of interleukin-1beta-converting enzyme and caspase-cleaved cytokeratin-18 in acute myocardial infarction
Eur. J. Clin. Invest.
37
372-380
2007
Homo sapiens
Li, J.; Yin, H.L.; Yuan, J.
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
J. Cell Biol.
181
321-333
2008
Mus musculus
Brough, D.; Rothwell, N.J.
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
J. Cell Sci.
120
772-781
2007
Mus musculus
Galle, M.; Schotte, P.; Haegman, M.; Wullaert, A.; Yang, H.J.; Jin, S.; Beyaert, R.
The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation
J. Cell. Mol. Med.
12
1767-1776
2008
Mus musculus
Cuesta, N.; Nhu, Q.M.; Zudaire, E.; Polumuri, S.; Cuttitta, F.; Vogel, S.N.
IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism
J. Immunol.
178
3602-3611
2007
Mus musculus
Pedra, J.H.; Sutterwala, F.S.; Sukumaran, B.; Ogura, Y.; Qian, F.; Montgomery, R.R.; Flavell, R.A.; Fikrig, E.
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
J. Immunol.
179
4783-4791
2007
Mus musculus
Johansen, C.; Moeller, K.; Kragballe, K.; Iversen, L.
The activity of caspase-1 is increased in lesional psoriatic epidermis
J. Invest. Dermatol.
127
2857-2864
2007
Homo sapiens
Lu, C.; Wang, Y.; Furukawa, K.; Fu, W.; Ouyang, X.; Mattson, M.P.
Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses
J. Neurochem.
97
1104-1110
2006
Rattus norvegicus
Schroeder, G.N.; Jann, N.J.; Hilbi, H.
Intracellular type III secretion by cytoplasmic Shigella flexneri promotes caspase-1-dependent macrophage cell death
Microbiology
153
2862-2876
2007
Mus musculus
Yang, D.; Chai, L.; Wang, J.; Zhao, X.
Molecular cloning and characterization of Hearm caspase-1 from Helicoverpa armigera
Mol. Biol. Rep.
35
405-412
2007
Helicoverpa armigera (A9Q0J3), Helicoverpa armigera
Juettler, E.; Bonmann, E.; Spranger, M.; Kolb-Bachofen, V.; Suschek, C.V.
A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases
Mol. Cell. Neurosci.
34
612-620
2007
Rattus norvegicus
Lopez-Castejon, G.; Sepulcre, M.P.; Mulero, I.; Pelegrin, P.; Meseguer, J.; Mulero, V.
Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish
Mol. Immunol.
45
49-57
2008
Sparus aurata
Miggin, S.M.; Palsson-McDermott, E.; Dunne, A.; Jefferies, C.; Pinteaux, E.; Banahan, K.; Murphy, C.; Moynagh, P.; Yamamoto, M.; Akira, S.; Rothwell, N.; Golenbock, D.; Fitzgerald, K.A.; ONeill, L.A.
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
Proc. Natl. Acad. Sci. USA
104
3372-3377
2007
Homo sapiens
Fink, S.L.; Bergsbaken, T.; Cookson, B.T.
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
Proc. Natl. Acad. Sci. USA
105
4312-4317
2008
Mus musculus
Kuijk, L.M.; Beekman, J.M.; Koster, J.; Waterham, H.R.; Frenkel, J.; Coffer, P.J.
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation
Blood
112
3563-3573
2008
Homo sapiens
Tseng, Y.K.; Wu, M.S.; Hou, R.F.
Induction of apoptosis in SF21 cell line by conditioned medium of the entomopathogenic fungus, Nomuraea rileyi, through Sf-caspase-1 signaling pathway
Arch. Insect Biochem. Physiol.
68
206-214
2008
Spodoptera frugiperda
Chae, J.J.; Wood, G.; Richard, K.; Jaffe, H.; Colburn, N.T.; Masters, S.L.; Gumucio, D.L.; Shoham, N.G.; Kastner, D.L.
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
Blood
112
1794-1803
2008
Homo sapiens
Yu, H.B.; Finlay, B.B.
The caspase-1 inflammasome: a pilot of innate immune responses
Cell Host Microbe
4
198-208
2008
Homo sapiens, Mus musculus
Reig, N.; Jiang, A.; Couture, R.; Sutterwala, F.S.; Ogura, Y.; Flavell, R.A.; Mellman, I.; van der Goot, F.G.
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin
Cell. Microbiol.
10
1190-1207
2008
Mus musculus
Levin, T.C.; Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin
Cell. Microbiol.
10
2434-2446
2008
Mus musculus, Mus musculus BALB/cJ
Roth, G.A.; Faybik, P.; Hetz, H.; Hacker, S.; Ankersmit, H.J.; Bacher, A.; Thalhammer, T.; Krenn, C.G.
Pro-inflammatory interleukin-18 and caspase-1 serum levels in liver failure are unaffected by MARS treatment
Dig. Liver Dis.
41
417-423
2008
Homo sapiens
Brough, D.; Pelegrin, P.; Rothwell, N.J.
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
Eur. J. Immunol.
39
352-358
2009
Mus musculus
Thomas, P.G.; Dash, P.; Aldridge, J.R.; Ellebedy, A.H.; Reynolds, C.; Funk, A.J.; Martin, W.J.; Lamkanfi, M.; Webby, R.J.; Boyd, K.L.; Doherty, P.C.; Kanneganti, T.D.
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
Immunity
30
566-575
2009
Mus musculus
Hurst, J.; Prinz, N.; Lorenz, M.; Bauer, S.; Chapman, J.; Lackner, K.J.; von Landenberg, P.
TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells
Immunobiology
214
683-691
2009
Homo sapiens
Case, C.L.; Shin, S.; Roy, C.R.
Asc and Ipaf inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
Infect. Immun.
17
1981-1991
2009
Mus musculus, Mus musculus C57BL/6
Shoma, S.; Tsuchiya, K.; Kawamura, I.; Nomura, T.; Hara, H.; Uchiyama, R.; Daim, S.; Mitsuyama, M.
Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation
Infect. Immun.
76
1547-1557
2008
Mus musculus
Lilo, S.; Zheng, Y.; Bliska, J.B.
Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ
Infect. Immun.
76
3911-3923
2008
Mus musculus
Breitbach, K.; Sun, G.W.; Koehler, J.; Eske, K.; Wongprompitak, P.; Tan, G.; Liu, Y.; Gan, Y.H.; Steinmetz, I.
Caspase-1 mediates resistance in murine melioidosis
Infect. Immun.
77
1589-1595
2009
Mus musculus
Hebert, C.G.; Valdes, J.J.; Bentley, W.E.
Investigating apoptosis: characterization and analysis of Trichoplusia ni-caspase-1 through overexpression and RNAi mediated silencing
Insect Biochem. Mol. Biol.
39
113-124
2009
Trichoplusia ni (B6EEC1), Trichoplusia ni
Marina-Garcia, N.; Franchi, L.; Kim, Y.G.; Miller, D.; McDonald, C.; Boons, G.J.; Nunez, G.
Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
J. Immunol.
180
4050-4057
2008
Mus musculus, Mus musculus C57BL/6
Hara, H.; Tsuchiya, K.; Nomura, T.; Kawamura, I.; Shoma, S.; Mitsuyama, M.
Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm
J. Immunol.
180
7859-7868
2008
Mus musculus
Kim, M.J.; Yoo, J.Y.
Active caspase-1-mediated secretion of retinoic acid inducible gene-I
J. Immunol.
181
7324-7331
2008
Homo sapiens
Qu, Y.; Ramachandra, L.; Mohr, S.; Franchi, L.; Harding, C.V.; Nunez, G.; Dubyak, G.R.
P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1
J. Immunol.
182
5052-5062
2009
Mus musculus, Mus musculus C57BL/6
Rosenzweig, H.L.; Martin, T.M.; Planck, S.R.; Galster, K.; Jann, M.M.; Davey, M.P.; Kobayashi, K.; Flavell, R.A.; Rosenbaum, J.T.
Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling
J. Leukoc. Biol.
84
529-536
2008
Mus musculus, Mus musculus BALB/c
Gotsch, F.; Romero, R.; Chaiworapongsa, T.; Erez, O.; Vaisbuch, E.; Espinoza, J.; Kusanovic, J.P.; Mittal, P.; Mazaki-Tovi, S.; Kim, C.J.; Kim, J.S.; Edwin, S.; Nhan-Chang, C.L.; Hamill, N.; Friel, L.; Than, N.G.; Mazor, M.; Yoon, B.H.; Hassan, S.S.
Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition
J. Matern. Fetal. Neonatal. Med.
21
605-616
2008
Homo sapiens
Datta, D.; Scheer, J.M.; Romanowski, M.J.; Wells, J.A.
An allosteric circuit in caspase-1
J. Mol. Biol.
381
1157-1167
2008
Homo sapiens
da Cunha, J.P.; Galante, P.A.; de Souza, S.J.
Different evolutionary strategies for the origin of caspase-1 inhibitors
J. Mol. Evol.
66
591-597
2008
Homo sapiens, Macaca mulatta, Pan troglodytes
Foley, K.; Kast, R.E.; Altschuler, E.L.
Ritonavir and disulfiram have potential to inhibit caspase-1 mediated inflammation and reduce neurological sequelae after minor blast exposure
Med. Hypotheses
72
150-152
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Lamkanfi, M.; Kanneganti, T.D.; Van Damme, P.; Vanden Berghe, T.; Vanoverberghe, I.; Vandekerckhove, J.; Vandenabeele, P.; Gevaert, K.; Nunez, G.
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
Mol. Cell. Proteomics
7
2350-2363
2008
Mus musculus, Mus musculus C57BL/6
Kuijk, L.M.; Mandey, S.H.; Schellens, I.; Waterham, H.R.; Rijkers, G.T.; Coffer, P.J.; Frenkel, J.
Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1
Mol. Immunol.
45
2158-2165
2008
Homo sapiens
Franchi, L.; Eigenbrod, T.; Munoz-Planillo, R.; Nunez, G.
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
Nat. Immunol.
10
241-247
2009
Homo sapiens, Mus musculus
Meissner, F.; Molawi, K.; Zychlinsky, A.
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Nat. Immunol.
9
866-872
2008
Homo sapiens
Hornung, V.; Ablasser, A.; Charrel-Dennis, M.; Bauernfeind, F.; Horvath, G.; Caffrey, D.R.; Latz, E.; Fitzgerald, K.A.
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Nature
458
514-518
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Hsu, L.C.; Ali, S.R.; McGillivray, S.; Tseng, P.H.; Mariathasan, S.; Humke, E.W.; Eckmann, L.; Powell, J.J.; Nizet, V.; Dixit, V.M.; Karin, M.
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
Proc. Natl. Acad. Sci. USA
105
7803-7808
2008
Mus musculus
Deng, X.; Tamai, R.; Endo, Y.; Kiyoura, Y.
Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1
Toxicol. Appl. Pharmacol.
235
97-104
2009
Mus musculus
Giamarellos-Bourboulis, E.; Mouktaroudi, M.; Bodar, E.; Van Der Ven, J.; Kullberg, B.; Netea, M.; Van Der Meer, J.
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1beta by mononuclear cells through a caspase 1-mediated process
Ann. Rheum. Dis.
68
273-278
2009
Homo sapiens
Guma, M.; Ronacher, L.; Liu-Bryan, R.; Takai, S.; Karin, M.; Corr, M.
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
Arthritis Rheum.
60
3642-3650
2009
Mus musculus
Joosten, L.A.; Netea, M.G.; Fantuzzi, G.; Koenders, M.I.; Helsen, M.M.; Sparrer, H.; Pham, C.T.; van der Meer, J.W.; Dinarello, C.A.; van den Berg, W.B.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
Arthritis Rheum.
60
3651-3662
2009
Mus musculus
Martin, T.M.; Zhang, Z.; Kurz, P.; Rose, C.D.; Chen, H.; Lu, H.; Planck, S.R.; Davey, M.P.; Rosenbaum, J.T.
The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity
Arthritis Rheum.
60
611-618
2009
Homo sapiens
Morishige, T.; Yoshioka, Y.; Tanabe, A.; Yao, X.; Tsunoda, S.; Tsutsumi, Y.; Mukai, Y.; Okada, N.; Nakagawa, S.
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B
Biochem. Biophys. Res. Commun.
392
160-165
2010
Homo sapiens
Boxer, M.B.; Quinn, A.M.; Shen, M.; Jadhav, A.; Leister, W.; Simeonov, A.; Auld, D.S.; Thomas, C.J.
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
ChemMedChem
5
730-738
2010
Homo sapiens
Vezzani, A.; Balosso, S.; Maroso, M.; Zardoni, D.; Noe, F.; Ravizza, T.
ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy
Curr. Opin. Investig. Drugs
11
43-50
2010
Homo sapiens
Chopra, P.; Gupta, S.; Dastidar, S.G.; Ray, A.
Development of cell death-based method for the selectivity screening of caspase-1 inhibitors
Cytotechnology
60
77-83
2009
Homo sapiens
Terada, K.; Yamada, J.; Hayashi, Y.; Wu, Z.; Uchiyama, Y.; Peters, C.; Nakanishi, H.
Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia
Glia
58
114-124
2010
Mus musculus
Kurenuma, T.; Kawamura, I.; Hara, H.; Uchiyama, R.; Daim, S.; Dewamitta, S.R.; Sakai, S.; Tsuchiya, K.; Nomura, T.; Mitsuyama, M.
The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages
Infect. Immun.
77
3992-4001
2009
Mus musculus
Prantner, D.; Darville, T.; Sikes, J.D.; Andrews, C.W.; Brade, H.; Rank, R.G.; Nagarajan, U.M.
Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages
Infect. Immun.
77
5334-5346
2009
Mus musculus
Cho, M.H.; Ahn, H.J.; Ha, H.J.; Park, J.; Chun, J.H.; Kim, B.S.; Oh, H.B.; Rhie, G.E.
Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells
Infect. Immun.
78
387-392
2010
Homo sapiens
Abdul-Sater, A.A.; Koo, E.; Haecker, G.; Ojcius, D.M.
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis
J. Biol. Chem.
284
26789-26796
2009
Homo sapiens
Okamoto, M.; Liu, W.; Luo, Y.; Tanaka, A.; Cai, X.; Norris, D.A.; Dinarello, C.A.; Fujita, M.
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
J. Biol. Chem.
285
6477-6488
2010
Homo sapiens
Ulrichts, P.; Bovijn, C.; Lievens, S.; Beyaert, R.; Tavernier, J.; Peelman, F.
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
J. Cell Sci.
123
256-265
2010
Homo sapiens
Bagchi, A.K.; Sinha, A.K.; Adhikari, R.; Maiti, P.; Mukherjee, J.; Panda, A.; Saha, D.R.
Selective deletion of CD8+ cells upregulated by caspases-1 via IL-18 in mice immunized with major outer membrane protein of Shigella dysenteriae 1 following infection
J. Clin. Immunol.
30
408-418
2010
Mus musculus
Keller, M.; Sollberger, G.; Beer, H.D.
Thalidomide inhibits activation of caspase-1
J. Immunol.
183
5593-5599
2009
Homo sapiens
Ohno, T.; Oboki, K.; Kajiwara, N.; Morii, E.; Aozasa, K.; Flavell, R.A.; Okumura, K.; Saito, H.; Nakae, S.
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages
J. Immunol.
183
7890-7897
2009
Mus musculus
Loeser, R.; Abbenante, G.; Madala, P.K.; Halili, M.; Le, G.T.; Fairlie, D.P.
Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1
J. Med. Chem.
53
2651-2655
2010
Homo sapiens
Nasirudeen, A.M.; Liu, D.X.
Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis
J. Med. Virol.
81
1069-1081
2009
Homo sapiens (P29466), Homo sapiens
Agard, N.J.; Maltby, D.; Wells, J.A.
Inflammatory stimuli regulate caspase substrate profiles
Mol. Cell. Proteomics
9
880-893
2010
Homo sapiens
Sarkar, A.; Mitra, S.; Mehta, S.; Raices, R.; Wewers, M.D.
Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1
PLoS ONE
4
e7140
2009
Homo sapiens
Shen, J.; Yin, Y.; Mai, J.; Xiong, X.; Pansuria, M.; Liu, J.; Maley, E.; Saqib, N.U.; Wang, H.; Yang, X.F.
Caspase-1 recognizes extended cleavage sites in its natural substrates
Atherosclerosis
210
422-429
2010
Homo sapiens
Weigert, A.; Cremer, S.; Schmidt, M.V.; von Knethen, A.; Angioni, C.; Geisslinger, G.; Bruene, B.
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
Blood
115
3531-3540
2010
Homo sapiens
White, J.; Beckford, J.; Yadegarynia, S.; Ngo, N.; Lialiutska, T.; DAlarcao, M.
Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity
Food Chem.
131
1453-1459
2012
Homo sapiens
Bergsbaken, T.; Fink, S.L.; den Hartigh, A.B.; Loomis, W.P.; Cookson, B.T.
Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation
J. Immunol.
187
2748-2754
2011
Mus musculus
Kang, T.J.; Lee, G.S.; Kim, S.K.; Jin, S.H.; Chae, G.T.
Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium leprae infection
Mediators Inflamm.
2010
708713
2010
Mus musculus
Williams, C.D.; Farhood, A.; Jaeschke, H.
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury
Toxicol. Appl. Pharmacol.
247
169-178
2010
Mus musculus
Moquin, A.; Hutter, E.; Choi, A.O.; Khatchadourian, A.; Castonguay, A.; Winnik, F.M.; Maysinger, D.
Caspase-1 activity in microglia stimulated by pro-inflammagen nanocrystals
ACS nano
7
9585-9598
2013
Mus musculus
Narayanan, K.B.; Park, H.H.
Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome
Appl. Biochem. Biotechnol.
175
2883-2894
2015
Homo sapiens
Juruj, C.; Lelogeais, V.; Pierini, R.; Perret, M.; Py, B.F.; Jamilloux, Y.; Broz, P.; Ader, F.; Faure, M.; Henry, T.
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
Front. Cell. Infect. Microbiol.
3
14
2013
Mus musculus
Luksch, H.; Romanowski, M.J.; Chara, O.; Tuengler, V.; Caffarena, E.R.; Heymann, M.C.; Lohse, P.; Aksentijevich, I.; Remmers, E.F.; Flecks, S.; Quoos, N.; Gramatte, J.; Petzold, C.; Hofmann, S.R.; Winkler, S.; Pessler, F.; Kallinich, T.; Ganser, G.; Nimtz-Talaska, A.; Baumann, U.; Runde, V.; Grimbacher, B., et al
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1beta
Hum. Mutat.
34
122-131
2013
Homo sapiens (P29466), Homo sapiens
Khoa, D.B.; Trang, L.T.; Takeda, M.
Expression analyses of caspase-1 and related activities in the midgut of Galleria mellonella during metamorphosis
Insect Mol. Biol.
21
247-256
2012
Galleria mellonella (F8UU16), Galleria mellonella
Datta, D.; McClendon, C.L.; Jacobson, M.P.; Wells, J.A.
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
J. Biol. Chem.
288
9971-9981
2013
Homo sapiens (P29466)
Hitzler, I.; Sayi, A.; Kohler, E.; Engler, D.B.; Koch, K.N.; Hardt, W.D.; Mueller, A.
Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18
J. Immunol.
188
3594-3602
2012
Mus musculus
Heymann, M.C.; Winkler, S.; Luksch, H.; Flecks, S.; Franke, M.; Russ, S.; Ozen, S.; Yilmaz, E.; Klein, C.; Kallinich, T.; Lindemann, D.; Brenner, S.; Ganser, G.; Roesler, J.; Roesen-Wolff, A.; Hofmann, S.R.
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-kappaB signaling
J. Immunol.
192
4379-4385
2014
Homo sapiens
Yamada, H.; Okamoto, K.; Kobayashi, M.; Ikeda, M.
Cloning and characterization of an effector caspase, Ld-caspase-1, from Lymantria dispar Ld652Y cells
J. Insect Biotechnol. Sericol.
81
75-83
2013
Lymantria dispar
-
Sollberger, G.; Strittmatter, G.E.; Grossi, S.; Garstkiewicz, M.; Auf dem Keller, U.; French, L.E.; Beer, H.D.
Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes
J. Invest. Dermatol.
135
1395-1404
2015
Homo sapiens
Stierle, D.B.; Stierle, A.A.; Girtsman, T.; McIntyre, K.; Nichols, J.
Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum
J. Nat. Prod.
75
262-266
2012
Homo sapiens
Puri, A.W.; Broz, P.; Shen, A.; Monack, D.M.; Bogyo, M.
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Nat. Chem. Biol.
8
745-747
2012
Mus musculus
Bulau, A.M.; Nold, M.F.; Li, S.; Nold-Petry, C.A.; Fink, M.; Mansell, A.; Schwerd, T.; Hong, J.; Rubartelli, A.; Dinarello, C.A.; Bufler, P.
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses
Proc. Natl. Acad. Sci. USA
111
2650-2655
2014
Mus musculus
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