Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-1 is activated in innate immune complexes called inflammasomes | Homo sapiens | |
thalidomide | thalidomide inhibits activation and activity of caspase-1 in cultured cells but not in vitro | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-Tyr-Val-Ala-Asp-chloromethylketone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | Homo sapiens | - |
mature interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | - |
Homo sapiens | mature interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? | |
WEDH + H2O | - |
Homo sapiens | ? | - |
? |