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Literature summary for 3.4.22.36 extracted from

  • Keller, M.; Sollberger, G.; Beer, H.D.
    Thalidomide inhibits activation of caspase-1 (2009), J. Immunol., 183, 5593-5599.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-1 is activated in innate immune complexes called inflammasomes Homo sapiens
thalidomide thalidomide inhibits activation and activity of caspase-1 in cultured cells but not in vitro Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Tyr-Val-Ala-Asp-chloromethylketone
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Homo sapiens
-
mature interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O Homo sapiens
-
mature interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
Homo sapiens mature interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O
-
Homo sapiens mature interleukin-1beta + ?
-
?
WEDH + H2O
-
Homo sapiens ?
-
?