Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of caspase-1 is induced in macrophages by Listeria monocytogenes infection depending on cytolysin and listeriolysin O, after evasion from phagosome into the cytoplasm, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-benzyloxycarbonyl-Tyr-Val-Ala-Asp-fluoromethyl ketone | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | Mus musculus | activation of caspase-1 as a key event resulting in interleukin-18 production, caspase-1 is essential for interleukin-18 production in infected macrophages | interleukin-18 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | wild-type and TLR4 knockout macrophage | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-18 + H2O | - |
Mus musculus | interleukin-18 + ? | - |
? | |
pro-interleukin-18 + H2O | activation of caspase-1 as a key event resulting in interleukin-18 production, caspase-1 is essential for interleukin-18 production in infected macrophages | Mus musculus | interleukin-18 + ? | - |
? |