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Literature summary for 3.4.22.36 extracted from

  • Nasirudeen, A.M.; Liu, D.X.
    Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis (2009), J. Med. Virol., 81, 1069-1081.
    View publication on PubMed
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
acetyl-YVAD-CHO caspase-1 specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Homo sapiens
-
 mature interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O Homo sapiens
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P29466
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H273 cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
 Homo sapiens mature interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?

Synonyms

Synonyms Comment Organism
apoptosis-related cysteine protease
-
 Homo sapiens
interleukin 1, beta, convertase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens an approximately 32fold increase in caspase-1 expression is observed in the p53-knockin cell line H273 up

General Information

General Information Comment Organism
malfunction gene silencing of caspase-1 or inhibition of caspase-1 activity leads to reduction in dengue virus-induced apoptosis with minimal effect on virus replication Homo sapiens