Protein Variants | Comment | Organism |
---|---|---|
C284A | inactive | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AWP28 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Mus musculus | - |
interleukin-1beta propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | - |
Mus musculus | interleukin-1beta propeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Casp1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | apoptosis is triggered upon bacterial infection in primary murine bone marrow macrophages lacking caspase-1 | Mus musculus |
physiological function | upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of pro-inflammatory pyroptotic cell death | Mus musculus |