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Literature summary for 3.4.22.36 extracted from

  • Deng, X.; Tamai, R.; Endo, Y.; Kiyoura, Y.
    Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1 (2009), Toxicol. Appl. Pharmacol., 235, 97-104.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
alendronate a nitrogen-containing bisphosphonate, activates caspase-1, activation is inhibited by clodronate. Pretreatment of cells with alendronate augments interleukin-1beta production stimulated by Toll-like receptor ligands, augmentation is inhibited by clodronate Mus musculus
additional information infection with periodontal pathogenic bacteria, e.g. Porphyromonas gingivalis and Tannerella forsythia, leads to activation of caspase-1 in macrophages, augmented by alendronate Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ac-YVAD-CHO a caspase-1 inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1 activation contributes to the development of nitrogen-containing bisphosphonate-associated inflammatory side effects including jaw osteomyelitis, overview ?
-
 ?
pro-interleukin-1beta + H2O Mus musculus
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 interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
J-774.1 cell macrophage-like cells Mus musculus
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macrophage macrophage-like J774.1 cells Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 activation contributes to the development of nitrogen-containing bisphosphonate-associated inflammatory side effects including jaw osteomyelitis, overview Mus musculus ?
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta + ?
-
 ?