Cloned (Comment) | Organism |
---|---|
co-expression of caspase-1 with wild-type and mutant, myc-tagged B30.2 domain-deleted pyrin, in PT67 cells, co-expression of wild-type pyrin, caspase-1, and interleukin-1beta in COS-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbobenzyloxy-Trp-Glu-His-Asp-fluoromethylketone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | pyrin and caspase-1 interact in their pathway for NF-kappaB activation, mechanism and regulation, overview | ? | - |
? | |
pyrin + H2O | Homo sapiens | caspase-1 cleaves pyrin at Asp330, Familial Mediterranean fever-associated mutants are cleaved more than wild-type pyrin by caspase-1. Pyrin itself regulates caspase-1 activation and interleukin-1beta production through interaction of its N-terminal PYD motif with the ASC adapterprotein, and also modulates interleukin-1beta production by interaction of its C-terminal B30.2 domain with the catalytic domains of caspase-1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | pyrin and caspase-1 interact in their pathway for NF-kappaB activation, mechanism and regulation, overview | Homo sapiens | ? | - |
? | |
pyrin + H2O | caspase-1 cleaves pyrin at Asp330, Familial Mediterranean fever-associated mutants are cleaved more than wild-type pyrin by caspase-1. Pyrin itself regulates caspase-1 activation and interleukin-1beta production through interaction of its N-terminal PYD motif with the ASC adapterprotein, and also modulates interleukin-1beta production by interaction of its C-terminal B30.2 domain with the catalytic domains of caspase-1 | Homo sapiens | ? | - |
? | |
pyrin + H2O | recombinant substrate expressed in PT67 cells | Homo sapiens | ? | - |
? |