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Literature summary for 3.4.22.36 extracted from

  • Yu, H.B.; Finlay, B.B.
    The caspase-1 inflammasome: a pilot of innate immune responses (2008), Cell Host Microbe, 4, 198-208.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-1 activation pathways and regulation, detailed overview. Many Gram-negative bacteria, such as Salmonella typhimurium, Pseudomonas aeruginosa, Shigella flexneri, and Legionella pneumophila, can induce caspase-1 activation and rapid macrophage cell death, the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1 Mus musculus
additional information caspase-1 activation pathways and regulation, detailed overview. Many Gram-negative bacteria, such as Salmonella typhimurium, Pseudomonas aeruginosa, Shigella flexneri, and Legionella pneumophila, can induce caspase-1 activation and rapid macrophage cell death, the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1, e.g. besides T3SS and flagellin, the host factor NLRC4 is also required for activation of caspase-1 by Salmonella typhimurium or Pseudomonas aeruginosa. Lipopolysaccharide-stimulated caspase-1 activation. Caspase-1 activation by NLRP1 does not require but is enhanced by adaptor protein ASC Homo sapiens
NLRC4 inflammasome
-
 Homo sapiens
NLRP1 inflammasome
-
 Homo sapiens
NLRP3 inflammasome
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 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information a dominant-negative form of the adaptor protein ASC in THP-1 cells blocks LPS-stimulated caspase-1 activation and interleukin-1beta secretion Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
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lysosome
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 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1 promotes the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 ?
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 ?
additional information Homo sapiens caspase-1 promotes the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 ?
-
 ?
additional information Mus musculus the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1. Proteins encoded by the nucleotide-binding domain and leucine-rich repeat, NLR, containing gene family form the central components of inflammasomes and act as intracellular sensors to detect cytosolic microbial components and danger signals, such as ATP and toxins, detailed overview. NLRs consist of three domains, besides others an N-terminal region including protein interaction domains such as the caspase recruitment domain ?
-
 ?
additional information Homo sapiens the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1. Proteins encoded by the nucleotide-binding domain and leucine-rich repeat, NLR, containing gene family form the central components of inflammasomes and act as intracellular sensors to detect cytosolic microbial components and danger signals, such as ATP and toxins, detailed overview. NLRs consist of three domains, besides others an N-terminal region including protein interaction domains such as the caspase recruitment domain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 promotes the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 Mus musculus ?
-
 ?
additional information caspase-1 promotes the maturation of proinflammatory cytokines interleukin-1beta and interleukin-18 Homo sapiens ?
-
 ?
additional information the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1. Proteins encoded by the nucleotide-binding domain and leucine-rich repeat, NLR, containing gene family form the central components of inflammasomes and act as intracellular sensors to detect cytosolic microbial components and danger signals, such as ATP and toxins, detailed overview. NLRs consist of three domains, besides others an N-terminal region including protein interaction domains such as the caspase recruitment domain Mus musculus ?
-
 ?
additional information the inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1. Proteins encoded by the nucleotide-binding domain and leucine-rich repeat, NLR, containing gene family form the central components of inflammasomes and act as intracellular sensors to detect cytosolic microbial components and danger signals, such as ATP and toxins, detailed overview. NLRs consist of three domains, besides others an N-terminal region including protein interaction domains such as the caspase recruitment domain Homo sapiens ?
-
 ?