Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-L-Leu-L-Glu-L-His-L-Asp-CHO | - |
Homo sapiens | |
IDN-6556 | active-site inhibitor that acts through irreversible covalent modification of the catalytic cysteine residue | Homo sapiens | |
L-Tyr-L-Val-L-Ala-L-Asp-CN | - |
Homo sapiens | |
NCGC00183434 | i.e. (S)-3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoic acid, competitive inhibition | Homo sapiens | |
NCGC00183681 | i.e. (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((S)-1-cyano-2-(1H-tetrazol-5-yl)ethyl)pyrrolidine-2-carboxamide | Homo sapiens | |
NCGC00185682 | i.e. 3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoate | Homo sapiens | |
pralnacasan | VX-740, active-site inhibitor that acts through reversible covalent modification of the catalytic cysteine residue | Homo sapiens | |
VRT-043198 | - |
Homo sapiens | |
VX-765 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(Z-LEHD)2-R110 tetrapeptide + H2O | - |
Homo sapiens | ? | - |
? | |
acetyl-L-Leu-L-Glu-L-His-L-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-L-Leu-L-Glu-L-His-L-Asp + 7-amino-4-methylcoumarin | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ICE | - |
Homo sapiens |
interleukin-converting enzyme | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000004 | - |
NCGC00183434 | in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000000023 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | NCGC00183434 | |
0.000000204 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | VRT-043198 | |
0.00000258 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | NCGC00183681 | |
0.000015 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | acetyl-L-Leu-L-Glu-L-His-L-Asp-CHO | |
0.0000216 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | L-Tyr-L-Val-L-Ala-L-Asp-CN | |
0.0000434 | - |
in 50 mM HEPES, pH 7.4, containing 1 M sodium citrate, 100 mM NaCl, 0.1 mM EDTA, 10 mM dithiothreitol, 0.01% (v/v) CHAPS, 1% (v/v) DMSO, and 0.1 mg/ml bovine serum albumin | Homo sapiens | NCGC00185682 |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase 1 is a major regulator of the inflammation response | Homo sapiens |