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Literature summary for 3.4.22.36 extracted from

  • Kuijk, L.M.; Beekman, J.M.; Koster, J.; Waterham, H.R.; Frenkel, J.; Coffer, P.J.
    HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation (2008), Blood, 112, 3563-3573.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of the Rac1/PI3K/protein kinase B pathway is required for caspase-1 activation mediating increased interleukin-1beta release Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular active mature enzyme Homo sapiens
-
-
lysosome inactive proenzyme Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens HMG-CoA reductase inhibition induces interleukin-1beta release through Rac1/PI3K/protein kinase B-dependent caspase-1 activation, overview. Caspase-1 is hyperactive in mevalonate kinase deficiency leading secretion of high levels of interleukin-1beta, regulation, overview mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell quantification of caspase-1 p20 subunit levels in culture supernatants of THP-1 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O HMG-CoA reductase inhibition induces interleukin-1beta release through Rac1/PI3K/protein kinase B-dependent caspase-1 activation, overview. Caspase-1 is hyperactive in mevalonate kinase deficiency leading secretion of high levels of interleukin-1beta, regulation, overview Homo sapiens mature interleukin-1beta + ?
-
 ?