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Literature summary for 3.4.22.36 extracted from

  • Marina-Garcia, N.; Franchi, L.; Kim, Y.G.; Miller, D.; McDonald, C.; Boons, G.J.; Nunez, G.
    Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2 (2008), J. Immunol., 180, 4050-4057.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-1 activation induced by MDP and ATP requires pore-forming pannexin-1, for delivery of the inducer MDP into the cell, and cryopyrin but is independent of Nod2 and NF-kappaB and MAPK signaling Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-1 activation induced by MDP and ATP requires pore-forming pannexin-1, for delivery of the inducer MDP into the cell, and cryopyrin but is independent of Nod2 ?
-
?
additional information Mus musculus C57BL/6 caspase-1 activation induced by MDP and ATP requires pore-forming pannexin-1, for delivery of the inducer MDP into the cell, and cryopyrin but is independent of Nod2 ?
-
?
pro-interleukin-18 + H2O Mus musculus
-
interleukin-18 + ?
-
?
pro-interleukin-18 + H2O Mus musculus C57BL/6
-
interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O Mus musculus
-
interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O Mus musculus C57BL/6
-
interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 activation induced by MDP and ATP requires pore-forming pannexin-1, for delivery of the inducer MDP into the cell, and cryopyrin but is independent of Nod2 Mus musculus ?
-
?
additional information caspase-1 activation induced by MDP and ATP requires pore-forming pannexin-1, for delivery of the inducer MDP into the cell, and cryopyrin but is independent of Nod2 Mus musculus C57BL/6 ?
-
?
pro-interleukin-18 + H2O
-
Mus musculus interleukin-18 + ?
-
?
pro-interleukin-18 + H2O
-
Mus musculus C57BL/6 interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O
-
Mus musculus interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O
-
Mus musculus C57BL/6 interleukin-1beta + ?
-
?