Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
monocyte expression analysis by quantitative real-time RT-PCR | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the downstream signaling pathway of TLR7 and TLR8 in monocytes and dendritic cells after stimulation with specific ligands included not only the secretion of cytokines, such as TNFalpha and interleukin-1beta, but as well the activation of necessary regulating proteins like caspase-1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | from peripheral blood | Homo sapiens | - |
monocyte | from peripheral blood | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the downstream signaling pathway of TLR7 and TLR8 in monocytes and dendritic cells after stimulation with specific ligands included not only the secretion of cytokines, such as TNFalpha and interleukin-1beta, but as well the activation of necessary regulating proteins like caspase-1 | Homo sapiens | ? | - |
? |