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Literature summary for 3.4.22.36 extracted from

  • Chopra, P.; Gupta, S.; Dastidar, S.G.; Ray, A.
    Development of cell death-based method for the selectivity screening of caspase-1 inhibitors (2009), Cytotechnology, 60, 77-83.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
L-Tyr-L-Val-L-Ala-L-Asp-CHO caspase-1-specific inhibitor Homo sapiens
additional information caspase-1 is not inhibited by Asp-Glu-Val-Asp-CHO, Ile-Glu-Thr-Asp-CHO, and Leu-Glu-His-Asp-CHO Homo sapiens
YN-1234 i.e. N-2-naphthoyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide Homo sapiens
Z-L-Val-L-Ala-L-Asp-fluoromethylketone broad-spectrum caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information caspase-1 activity is not detected in Jurkat cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-YVAD-4-nitroanilide + H2O
-
 Homo sapiens acetyl-YVAD + 4-nitroaniline
-
 ?
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?

Synonyms

Synonyms Comment Organism
ICE
-
 Homo sapiens
interleukin converting enzyme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
-
 Homo sapiens L-Tyr-L-Val-L-Ala-L-Asp-CHO
0.000024
-
-
 Homo sapiens YN-1234

General Information

General Information Comment Organism
physiological function caspase-1 is mainly involved in cytokine maturation, leading to an inflammatory response Homo sapiens