Literature summary for 3.4.22.36 extracted from

Fink, S.L.; Cookson, B.T.
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages (2006), Cell. Microbiol., 8, 1812-1825.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
J-774A.1 cell	Salmonella enterica serovar typhimurium invades host macrophages and induces a unique caspase-1-dependent pathway of cell death termed pyroptosis, which is activated during bacterial infection in vivo. DNA cleavage during pyroptosis results from caspase-1-stimulated nuclease activity. Membrane pores between 1.1 and 2.4 nm in diameter form during pyroptosis of host cells and cause swelling and osmotic lysis. Pore formation requires host cell actin cytoskeleton rearrangements and caspase-1 activity, as well as the bacterial type III secretion system	Mus musculus	-

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Release 2023.1 (January 2023)