Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-YVAD-chloromethylketone | inhibition of caspase-1 with Ac-YVAD-CMK prevents SphK2 cleavage | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine kinase 2 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine kinase 2 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | release of truncated SphK2 into the supernatant is attenuated in caspase-1 knockdown cells | Homo sapiens |
physiological function | during cell death, sphingosine kinase 2 (SphK2) is cleaved at its N-terminus in a caspase-1-dependent manner. A truncated but enzymatically active fragment of SphK2 is released from cells | Homo sapiens |